Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T‐cell leukemia

Adult T‐cell leukemia (ATL) has a poor prognosis as a result of severe immunosuppression and rapid tumor progression with resistance to conventional chemotherapy. Recent integrated‐genome analysis has revealed mutations in many genes involved in the T‐cell signaling pathway, suggesting that the aber...

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Detalles Bibliográficos
Autores principales: Kawata, Takahito, Tada, Kohei, Kobayashi, Masayuki, Sakamoto, Takashi, Takiuchi, Yoko, Iwai, Fumie, Sakurada, Maki, Hishizawa, Masakatsu, Shirakawa, Kotaro, Shindo, Keisuke, Sato, Hironori, Takaori‐Kondo, Akifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765289/
https://www.ncbi.nlm.nih.gov/pubmed/29077243
http://dx.doi.org/10.1111/cas.13431

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