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Lipidomics Reveals Dramatic Physiological Kinetic Isotope Effects during the Enzymatic Oxygenation of Polyunsaturated Fatty Acids Ex Vivo

[Image: see text] Arachidonic acid (AA, 20:4) is an omega-6 polyunsaturated fatty acid (PUFA) and the main precursor to the class of lipid mediators known as eicosanoids. The enzymes that catalyze the oxygenation of AA begin by abstracting hydrogen from one of three bis-allylic carbons within 1,4-ci...

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Detalles Bibliográficos
Autores principales:	Navratil, Aaron R., Shchepinov, Mikhail S., Dennis, Edward A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765537/ https://www.ncbi.nlm.nih.gov/pubmed/29206462 http://dx.doi.org/10.1021/jacs.7b09493

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