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Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib

Upon DNA binding the poly(ADP-ribose) polymerase family of enzymes (PARPs) add multiple ADP-ribose subunits to themselves and other acceptor proteins. Inhibitors of PARPs have become an exciting and real prospect for monotherapy and as sensitizers to ionising radiation (IR). The action of PARPs are...

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Detalles Bibliográficos
Autores principales:	Gravells, Polly, Neale, James, Grant, Emma, Nathubhai, Amit, Smith, Kate M., James, Dominic I., Bryant, Helen E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765821/ https://www.ncbi.nlm.nih.gov/pubmed/29179156 http://dx.doi.org/10.1016/j.dnarep.2017.11.004

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