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QT-interval prolongation due to medication found in the preoperative evaluation
QT prolongation is an electrocardiographic change that can lead to lethal arrhythmia. Acquired QT prolongation is known to be caused by drugs and electrolyte abnormalities. We report three cases in which the prolonged QT interval was improved at the time of operation by briefly discontinuing the dru...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Dental Society of Anesthsiology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766086/ https://www.ncbi.nlm.nih.gov/pubmed/29349356 http://dx.doi.org/10.17245/jdapm.2017.17.4.323 |
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author | Seto, Mika Koga, Sayo Kita, Ryosuke Kikuta, Toshihiro |
author_facet | Seto, Mika Koga, Sayo Kita, Ryosuke Kikuta, Toshihiro |
author_sort | Seto, Mika |
collection | PubMed |
description | QT prolongation is an electrocardiographic change that can lead to lethal arrhythmia. Acquired QT prolongation is known to be caused by drugs and electrolyte abnormalities. We report three cases in which the prolonged QT interval was improved at the time of operation by briefly discontinuing the drugs suspected to have caused the QT prolongation observed on preoperative electrocardiography. The QTc of cases 1, 2, and 3 improved from 518 to 429 ms, 463 to 441 ms, and 473 to 443 ms on discontinuing the use of a gastrointestinal prokinetic agent, a proton pump inhibitor, and a molecular targeted drug, respectively. These cases were considered to have drug-induced QT prolongation. We reaffirmed that even drugs administered for conditions unrelated to cardiac diseases can have adverse side effect of QT prolongation. In conclusion, our cases indicate that dental surgeons should be aware of the dangerous and even potentially lethal side effects of QT prolongation. For safe oral and maxillofacial surgery, cooperation with medical departments in various fields is important. |
format | Online Article Text |
id | pubmed-5766086 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Korean Dental Society of Anesthsiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-57660862018-01-18 QT-interval prolongation due to medication found in the preoperative evaluation Seto, Mika Koga, Sayo Kita, Ryosuke Kikuta, Toshihiro J Dent Anesth Pain Med Case Report QT prolongation is an electrocardiographic change that can lead to lethal arrhythmia. Acquired QT prolongation is known to be caused by drugs and electrolyte abnormalities. We report three cases in which the prolonged QT interval was improved at the time of operation by briefly discontinuing the drugs suspected to have caused the QT prolongation observed on preoperative electrocardiography. The QTc of cases 1, 2, and 3 improved from 518 to 429 ms, 463 to 441 ms, and 473 to 443 ms on discontinuing the use of a gastrointestinal prokinetic agent, a proton pump inhibitor, and a molecular targeted drug, respectively. These cases were considered to have drug-induced QT prolongation. We reaffirmed that even drugs administered for conditions unrelated to cardiac diseases can have adverse side effect of QT prolongation. In conclusion, our cases indicate that dental surgeons should be aware of the dangerous and even potentially lethal side effects of QT prolongation. For safe oral and maxillofacial surgery, cooperation with medical departments in various fields is important. The Korean Dental Society of Anesthsiology 2017-12 2017-12-28 /pmc/articles/PMC5766086/ /pubmed/29349356 http://dx.doi.org/10.17245/jdapm.2017.17.4.323 Text en Copyright © 2017 Journal of Dental Anesthesia and Pain Medicine http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Seto, Mika Koga, Sayo Kita, Ryosuke Kikuta, Toshihiro QT-interval prolongation due to medication found in the preoperative evaluation |
title | QT-interval prolongation due to medication found in the preoperative evaluation |
title_full | QT-interval prolongation due to medication found in the preoperative evaluation |
title_fullStr | QT-interval prolongation due to medication found in the preoperative evaluation |
title_full_unstemmed | QT-interval prolongation due to medication found in the preoperative evaluation |
title_short | QT-interval prolongation due to medication found in the preoperative evaluation |
title_sort | qt-interval prolongation due to medication found in the preoperative evaluation |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766086/ https://www.ncbi.nlm.nih.gov/pubmed/29349356 http://dx.doi.org/10.17245/jdapm.2017.17.4.323 |
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