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Role of N-glycosylation in activation of proMMP-9. A molecular dynamics simulations study
Human matrix metalloproteinase proMMP-9 is secreted as latent zymogen, which requires two-steps proteolytic activation. The secreted proMMP-9 is glycosylated at two positions: Asn38 and Asn120 located in the prodomain and catalytic domain, respectively. It has been demonstrated that glycosylation at...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766141/ https://www.ncbi.nlm.nih.gov/pubmed/29329315 http://dx.doi.org/10.1371/journal.pone.0191157 |