The conserved AU dinucleotide at the 5′ end of nascent U1 snRNA is optimized for the interaction with nuclear cap-binding-complex

Splicing is initiated by a productive interaction between the pre-mRNA and the U1 snRNP, in which a short RNA duplex is established between the 5′ splice site of a pre-mRNA and the 5′ end of the U1 snRNA. A long-standing puzzle has been why the AU dincucleotide at the 5′-end of the U1 snRNA is highl...

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Detalles Bibliográficos
Autores principales: Yeh, Chung-Shu, Chang, Shang-Lin, Chen, Jui­-Hui, Wang, Hsuan-Kai, Chou, Yue-Chang, Wang, Chun-Hsiung, Huang, Shih-Hsin, Larson, Amy, Pleiss, Jeffrey A, Chang, Wei-Hau, Chang, Tien-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766165/
https://www.ncbi.nlm.nih.gov/pubmed/28934473
http://dx.doi.org/10.1093/nar/gkx608

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