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Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins

Antibiotics methymycin (MTM) and pikromycin (PKM), co-produced by Streptomyces venezuelae, represent minimalist macrolide protein synthesis inhibitors. Unlike other macrolides, which carry several side chains, a single desosamine sugar is attached to the macrolactone ring of MTM and PKM. In addition...

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Detalles Bibliográficos
Autores principales:	Almutairi, Mashal M., Svetlov, Maxim S., Hansen, Douglas A., Khabibullina, Nelli F., Klepacki, Dorota, Kang, Han-Young, Sherman, David H., Vázquez-Laslop, Nora, Polikanov, Yury S., Mankin, Alexander S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766166/ https://www.ncbi.nlm.nih.gov/pubmed/28934499 http://dx.doi.org/10.1093/nar/gkx673

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