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Antisense oligonucleotides targeting translation inhibitory elements in 5′ UTRs can selectively increase protein levels

A variety of diseases are caused by deficiencies in amounts or activity of key proteins. An approach that increases the amount of a specific protein might be of therapeutic benefit. We reasoned that translation could be specifically enhanced using trans-acting agents that counter the function of neg...

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Detalles Bibliográficos
Autores principales:	Liang, Xue-hai, Sun, Hong, Shen, Wen, Wang, Shiyu, Yao, Joyee, Migawa, Michael T., Bui, Huynh-Hoa, Damle, Sagar S., Riney, Stan, Graham, Mark J., Crooke, Rosanne M., Crooke, Stanley T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766168/ https://www.ncbi.nlm.nih.gov/pubmed/28934489 http://dx.doi.org/10.1093/nar/gkx632

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