Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state

The T cell compartment must contain diversity in both T cell receptor (TCR) repertoire and cell state to provide effective immunity against pathogens. However, it remains unclear how differences in the TCR contribute to heterogeneity in T cell state. Single cell RNA-sequencing (scRNA-seq) can allow...

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Detalles Bibliográficos
Autores principales: Afik, Shaked, Yates, Kathleen B., Bi, Kevin, Darko, Samuel, Godec, Jernej, Gerdemann, Ulrike, Swadling, Leo, Douek, Daniel C., Klenerman, Paul, Barnes, Eleanor J., Sharpe, Arlene H., Haining, W. Nicholas, Yosef, Nir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766189/
https://www.ncbi.nlm.nih.gov/pubmed/28934479
http://dx.doi.org/10.1093/nar/gkx615

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