Crystal structure of an engineered, HIV-specific recombinase for removal of integrated proviral DNA

As part of the HIV infection cycle, viral DNA inserts into the genome of host cells such that the integrated DNA encoding the viral proteins is flanked by long terminal repeat (LTR) regions from the retrovirus. In an effort to develop novel genome editing techniques that safely excise HIV provirus f...

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Detalles Bibliográficos
Autores principales: Meinke, Gretchen, Karpinski, Janet, Buchholz, Frank, Bohm, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766204/
https://www.ncbi.nlm.nih.gov/pubmed/28934476
http://dx.doi.org/10.1093/nar/gkx603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766204/
https://www.ncbi.nlm.nih.gov/pubmed/28934476
http://dx.doi.org/10.1093/nar/gkx603

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