Cargando…
Disulfide isomerization reactions in titin immunoglobulin domains enable a mode of protein elasticity
The response of titin to mechanical forces is a major determinant of the function of the heart. When placed under a pulling force, the unstructured regions of titin uncoil while its immunoglobulin (Ig) domains unfold and extend. Using single-molecule atomic force microscopy, we show that disulfide i...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766482/ https://www.ncbi.nlm.nih.gov/pubmed/29330363 http://dx.doi.org/10.1038/s41467-017-02528-7 |