RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

Analysis of 501 melanoma exomes revealed RGS7, which encodes a GTPase-accelerating protein (GAP), to be a tumor-suppressor gene. RGS7 was mutated in 11% of melanomas and was found to harbor three recurrent mutations (p.R44C, p.E383K and p.R416Q). Structural modeling of the most common recurrent muta...

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Detalles Bibliográficos
Autores principales: Qutob, Nouar, Masuho, Ikuo, Alon, Michal, Emmanuel, Rafi, Cohen, Isadora, Di Pizio, Antonella, Madore, Jason, Elkahloun, Abdel, Ziv, Tamar, Levy, Ronen, Gartner, Jared J., Hill, Victoria K., Lin, Jimmy C., Hevroni, Yael, Greenberg, Polina, Brodezki, Alexandra, Rosenberg, Steven A., Kosloff, Mickey, Hayward, Nicholas K., Admon, Arie, Niv, Masha Y., Scolyer, Richard A., Martemyanov, Kirill A., Samuels, Yardena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766496/
https://www.ncbi.nlm.nih.gov/pubmed/29330521
http://dx.doi.org/10.1038/s41598-017-18851-4

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