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Autapses promote synchronization in neuronal networks
Neurological disorders such as epileptic seizures are believed to be caused by neuronal synchrony. However, to ascertain the causal role of neuronal synchronization in such diseases through the traditional approach of electrophysiological data analysis remains a controversial, challenging, and outst...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766500/ https://www.ncbi.nlm.nih.gov/pubmed/29330551 http://dx.doi.org/10.1038/s41598-017-19028-9 |
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author | Fan, Huawei Wang, Yafeng Wang, Hengtong Lai, Ying-Cheng Wang, Xingang |
author_facet | Fan, Huawei Wang, Yafeng Wang, Hengtong Lai, Ying-Cheng Wang, Xingang |
author_sort | Fan, Huawei |
collection | PubMed |
description | Neurological disorders such as epileptic seizures are believed to be caused by neuronal synchrony. However, to ascertain the causal role of neuronal synchronization in such diseases through the traditional approach of electrophysiological data analysis remains a controversial, challenging, and outstanding problem. We offer an alternative principle to assess the physiological role of neuronal synchrony based on identifying structural anomalies in the underlying network and studying their impacts on the collective dynamics. In particular, we focus on autapses - time delayed self-feedback links that exist on a small fraction of neurons in the network, and investigate their impacts on network synchronization through a detailed stability analysis. Our main finding is that the proper placement of a small number of autapses in the network can promote synchronization significantly, providing the computational and theoretical bases for hypothesizing a high degree of synchrony in real neuronal networks with autapses. Our result that autapses, the shortest possible links in any network, can effectively modulate the collective dynamics provides also a viable strategy for optimal control of complex network dynamics at minimal cost. |
format | Online Article Text |
id | pubmed-5766500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57665002018-01-17 Autapses promote synchronization in neuronal networks Fan, Huawei Wang, Yafeng Wang, Hengtong Lai, Ying-Cheng Wang, Xingang Sci Rep Article Neurological disorders such as epileptic seizures are believed to be caused by neuronal synchrony. However, to ascertain the causal role of neuronal synchronization in such diseases through the traditional approach of electrophysiological data analysis remains a controversial, challenging, and outstanding problem. We offer an alternative principle to assess the physiological role of neuronal synchrony based on identifying structural anomalies in the underlying network and studying their impacts on the collective dynamics. In particular, we focus on autapses - time delayed self-feedback links that exist on a small fraction of neurons in the network, and investigate their impacts on network synchronization through a detailed stability analysis. Our main finding is that the proper placement of a small number of autapses in the network can promote synchronization significantly, providing the computational and theoretical bases for hypothesizing a high degree of synchrony in real neuronal networks with autapses. Our result that autapses, the shortest possible links in any network, can effectively modulate the collective dynamics provides also a viable strategy for optimal control of complex network dynamics at minimal cost. Nature Publishing Group UK 2018-01-12 /pmc/articles/PMC5766500/ /pubmed/29330551 http://dx.doi.org/10.1038/s41598-017-19028-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Fan, Huawei Wang, Yafeng Wang, Hengtong Lai, Ying-Cheng Wang, Xingang Autapses promote synchronization in neuronal networks |
title | Autapses promote synchronization in neuronal networks |
title_full | Autapses promote synchronization in neuronal networks |
title_fullStr | Autapses promote synchronization in neuronal networks |
title_full_unstemmed | Autapses promote synchronization in neuronal networks |
title_short | Autapses promote synchronization in neuronal networks |
title_sort | autapses promote synchronization in neuronal networks |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766500/ https://www.ncbi.nlm.nih.gov/pubmed/29330551 http://dx.doi.org/10.1038/s41598-017-19028-9 |
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