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Autapses promote synchronization in neuronal networks

Neurological disorders such as epileptic seizures are believed to be caused by neuronal synchrony. However, to ascertain the causal role of neuronal synchronization in such diseases through the traditional approach of electrophysiological data analysis remains a controversial, challenging, and outst...

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Autores principales: Fan, Huawei, Wang, Yafeng, Wang, Hengtong, Lai, Ying-Cheng, Wang, Xingang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766500/
https://www.ncbi.nlm.nih.gov/pubmed/29330551
http://dx.doi.org/10.1038/s41598-017-19028-9
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author Fan, Huawei
Wang, Yafeng
Wang, Hengtong
Lai, Ying-Cheng
Wang, Xingang
author_facet Fan, Huawei
Wang, Yafeng
Wang, Hengtong
Lai, Ying-Cheng
Wang, Xingang
author_sort Fan, Huawei
collection PubMed
description Neurological disorders such as epileptic seizures are believed to be caused by neuronal synchrony. However, to ascertain the causal role of neuronal synchronization in such diseases through the traditional approach of electrophysiological data analysis remains a controversial, challenging, and outstanding problem. We offer an alternative principle to assess the physiological role of neuronal synchrony based on identifying structural anomalies in the underlying network and studying their impacts on the collective dynamics. In particular, we focus on autapses - time delayed self-feedback links that exist on a small fraction of neurons in the network, and investigate their impacts on network synchronization through a detailed stability analysis. Our main finding is that the proper placement of a small number of autapses in the network can promote synchronization significantly, providing the computational and theoretical bases for hypothesizing a high degree of synchrony in real neuronal networks with autapses. Our result that autapses, the shortest possible links in any network, can effectively modulate the collective dynamics provides also a viable strategy for optimal control of complex network dynamics at minimal cost.
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spelling pubmed-57665002018-01-17 Autapses promote synchronization in neuronal networks Fan, Huawei Wang, Yafeng Wang, Hengtong Lai, Ying-Cheng Wang, Xingang Sci Rep Article Neurological disorders such as epileptic seizures are believed to be caused by neuronal synchrony. However, to ascertain the causal role of neuronal synchronization in such diseases through the traditional approach of electrophysiological data analysis remains a controversial, challenging, and outstanding problem. We offer an alternative principle to assess the physiological role of neuronal synchrony based on identifying structural anomalies in the underlying network and studying their impacts on the collective dynamics. In particular, we focus on autapses - time delayed self-feedback links that exist on a small fraction of neurons in the network, and investigate their impacts on network synchronization through a detailed stability analysis. Our main finding is that the proper placement of a small number of autapses in the network can promote synchronization significantly, providing the computational and theoretical bases for hypothesizing a high degree of synchrony in real neuronal networks with autapses. Our result that autapses, the shortest possible links in any network, can effectively modulate the collective dynamics provides also a viable strategy for optimal control of complex network dynamics at minimal cost. Nature Publishing Group UK 2018-01-12 /pmc/articles/PMC5766500/ /pubmed/29330551 http://dx.doi.org/10.1038/s41598-017-19028-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Fan, Huawei
Wang, Yafeng
Wang, Hengtong
Lai, Ying-Cheng
Wang, Xingang
Autapses promote synchronization in neuronal networks
title Autapses promote synchronization in neuronal networks
title_full Autapses promote synchronization in neuronal networks
title_fullStr Autapses promote synchronization in neuronal networks
title_full_unstemmed Autapses promote synchronization in neuronal networks
title_short Autapses promote synchronization in neuronal networks
title_sort autapses promote synchronization in neuronal networks
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766500/
https://www.ncbi.nlm.nih.gov/pubmed/29330551
http://dx.doi.org/10.1038/s41598-017-19028-9
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