A Computational Assay of Estrogen Receptor α Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers

Somatic mutations of the Estrogen Receptor α (ERα) occur with an up to 40% incidence in ER sensitive breast cancer (BC) patients undergoing prolonged endocrine treatments. These polymorphisms are implicated in acquired resistance, disease relapse, and increased mortality rates, hence representing a...

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Detalles Bibliográficos
Autores principales: Pavlin, Matic, Spinello, Angelo, Pennati, Marzia, Zaffaroni, Nadia, Gobbi, Silvia, Bisi, Alessandra, Colombo, Giorgio, Magistrato, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766519/
https://www.ncbi.nlm.nih.gov/pubmed/29330437
http://dx.doi.org/10.1038/s41598-017-17364-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766519/
https://www.ncbi.nlm.nih.gov/pubmed/29330437
http://dx.doi.org/10.1038/s41598-017-17364-4

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