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Targeting Insulin-Like Growth Factor-I and Extracellular Matrix Interactions in Melanoma Progression

Insulin-like growth factor (IGF)-I binds to the ECM protein vitronectin (VN) through IGF binding proteins (IGFBPs) to enhance proliferation and migration of skin keratinocytes and fibroblasts. Although evidence exists for the role of individual components of the complex (IGF-I, IGFBP-3 and VN), the...

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Detalles Bibliográficos
Autores principales:	Murekatete, Berline, Shokoohmand, Ali, McGovern, Jacqui, Mohanty, Lipsa, Meinert, Christoph, Hollier, Brett G., Zippelius, Alfred, Upton, Zee, Kashyap, Abhishek S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766529/ https://www.ncbi.nlm.nih.gov/pubmed/29330502 http://dx.doi.org/10.1038/s41598-017-19073-4

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