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The Structure of Metal Binding Domain 1 of the Copper Transporter ATP7B Reveals Mechanism of a Singular Wilson Disease Mutation

Copper-transporter ATP7B maintains copper homeostasis in the human cells and delivers copper to the biosynthetic pathways for incorporation into the newly synthesized copper-containing proteins. ATP7B is a target of several hundred mutations that lead to Wilson disease, a chronic copper toxicosis. A...

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Detalles Bibliográficos
Autores principales:	Yu, Corey H., Lee, Woonghee, Nokhrin, Sergiy, Dmitriev, Oleg Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766562/ https://www.ncbi.nlm.nih.gov/pubmed/29330485 http://dx.doi.org/10.1038/s41598-017-18951-1

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