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Characterization of human small heat shock protein HSPB1 α-crystallin domain localized mutants associated with hereditary motor neuron diseases

Congenital mutations in human small heat shock protein HSPB1 (HSP27) have been linked to Charcot-Marie-Tooth disease, a commonly occurring peripheral neuropathy. Understanding the molecular mechanism of such mutations is indispensable towards developing future therapies for this currently incurable...

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Detalles Bibliográficos
Autores principales:	Weeks, Stephen D., Muranova, Lydia K., Heirbaut, Michelle, Beelen, Steven, Strelkov, Sergei V., Gusev, Nikolai B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766566/ https://www.ncbi.nlm.nih.gov/pubmed/29330367 http://dx.doi.org/10.1038/s41598-017-18874-x

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