Single-cell RNA-sequencing resolves self-antigen expression during mTEC development

The crucial capability of T cells for discrimination between self and non-self peptides is based on negative selection of developing thymocytes by medullary thymic epithelial cells (mTECs). The mTECs purge autoreactive T cells by expression of cell-type specific genes referred to as tissue-restricte...

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Detalles Bibliográficos
Autores principales: Miragaia, Ricardo J., Zhang, Xiuwei, Gomes, Tomás, Svensson, Valentine, Ilicic, Tomislav, Henriksson, Johan, Kar, Gozde, Lönnberg, Tapio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766627/
https://www.ncbi.nlm.nih.gov/pubmed/29330484
http://dx.doi.org/10.1038/s41598-017-19100-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766627/
https://www.ncbi.nlm.nih.gov/pubmed/29330484
http://dx.doi.org/10.1038/s41598-017-19100-4

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