Cargando…

Uncovering the anticancer mechanism of Compound Kushen Injection against HCC by integrating quantitative analysis, network analysis and experimental validation

Compound Kushen Injection (CKI) is a Traditional Chinese Medicine (TCM) preparation that has been clinically used in China to treat various types of solid tumours. Although several studies have revealed that CKI can inhibit the proliferation of hepatocellular carcinoma (HCC) cell lines, the active c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Li, Wang, Ke-xin, Zhou, Yu-zhi, Fang, Jian-song, Qin, Xue-mei, Du, Guan-hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766629/ https://www.ncbi.nlm.nih.gov/pubmed/29330507 http://dx.doi.org/10.1038/s41598-017-18325-7

Ejemplares similares

Aidi Injection, Compound Kushen Injection, or Kanglaite Injection: Which Is the Best Partner with Systemic Chemotherapy for Patients with HCC? A Network Meta-Analysis
por: Dou, Dou, et al.
Publicado: (2020)

Understanding the Mechanistic Contribution of Herbal Extracts in Compound Kushen Injection With Transcriptome Analysis
por: Shen, Hanyuan, et al.
Publicado: (2019)

Effects of compound Kushen injection on pathology and angiogenesis of tumor tissues
por: Wang, Hongyan, et al.
Publicado: (2019)

Compound Kushen Injection for gastric cancer: A protocol of systematic review and meta-analysis
por: Huang, Zhihong, et al.
Publicado: (2019)

Compound kushen injection for multiple myeloma: A protocol of systematic review and meta-analysis
por: Yang, Xinwei, et al.
Publicado: (2019)

Single-cell RNA-sequencing uncovers compound kushen injection synergistically improves the efficacy of chemotherapy by modulating the tumor environment of breast cancer
por: Liu, Xinkui, et al.
Publicado: (2022)

Mechanisms of Compound Kushen Injection for the Treatment of Lung Cancer Based on Network Pharmacology
por: Meng, Ziqi, et al.
Publicado: (2019)

Compound Kushen injection reduces severity of radiation-induced gastrointestinal mucositis in rats
por: Harata-Lee, Yuka, et al.
Publicado: (2022)

Efficacy of Compound Kushen Injection in Relieving Cancer-Related Pain: A Systematic Review and Meta-Analysis
por: Guo, Yu-ming, et al.
Publicado: (2015)

Can Kushen injection combined with TACE improve therapeutic efficacy and safety in patients with advanced HCC? a systematic review and network meta-analysis
por: Zhang, Yingshi, et al.
Publicado: (2017)

Cell cycle arrest is an important mechanism of action of compound Kushen injection in the prevention of colorectal cancer
por: Sun, Jie, et al.
Publicado: (2022)

A System Pharmacology Model for Decoding the Synergistic Mechanisms of Compound Kushen Injection in Treating Breast Cancer
por: Li, Yi, et al.
Publicado: (2021)

The effect of compound kushen injection on cancer cells: Integrated identification of candidate molecular mechanisms
por: Cui, Jian, et al.
Publicado: (2020)

Study on the mechanisms of compound Kushen injection for the treatment of gastric cancer based on network pharmacology
por: Zhou, Wei, et al.
Publicado: (2020)

Compound Kushen Injection Protects Skin From Radiation Injury via Regulating Bim
por: Zheng, Jianxiao, et al.
Publicado: (2021)

Antioxidant and Immunity Activities of Fufang Kushen Injection Liquid
por: Zhou, Shen-Kang, et al.
Publicado: (2012)

Efficacy and Safety of Compound Kushen Injection on Patients with Advanced Colon Cancer: A Meta-Analysis of Randomized Controlled Trials
por: Yu, Lixiu, et al.
Publicado: (2017)

Integrated bioinformatics analysis to decipher molecular mechanism of compound Kushen injection for esophageal cancer by combining WGCNA with network pharmacology
por: Zhou, Wei, et al.
Publicado: (2020)

Identification of candidate anti-cancer molecular mechanisms of Compound Kushen Injection using functional genomics
por: Qu, Zhipeng, et al.
Publicado: (2016)

The feasibility of using the compound kushen injection to treat cervical cancer based on network pharmacology and transcriptomics
por: Zhang, Yiting, et al.
Publicado: (2023)

Evaluation of efficacy and safety for compound kushen injection combined with intraperitoneal chemotherapy for patients with malignant ascites: A systematic review and meta-analysis
por: Yu, Hui-Bo, et al.
Publicado: (2023)

The Therapeutic Efficacy and Safety of Compound Kushen Injection Combined with Transarterial Chemoembolization in Unresectable Hepatocellular Carcinoma: An Update Systematic Review and Meta-Analysis
por: Ma, Xiao, et al.
Publicado: (2016)

Fractional Deletion of Compound Kushen Injection Indicates Cytokine Signaling Pathways are Critical for its Perturbation of the Cell Cycle
por: Aung, T. N., et al.
Publicado: (2019)

An advanced network pharmacology study to explore the novel molecular mechanism of Compound Kushen Injection for treating hepatocellular carcinoma by bioinformatics and experimental verification
por: Lu, Shan, et al.
Publicado: (2022)

Cell cycle, energy metabolism and DNA repair pathways in cancer cells are suppressed by Compound Kushen Injection
por: Cui, Jian, et al.
Publicado: (2019)

A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation
por: Wu, Chao, et al.
Publicado: (2021)

Compound Kushen injection attenuates angiotensin II-mediated heart failure by inhibiting the PI3K/Akt pathway
por: Wang, Wei, et al.
Publicado: (2023)

Association Rule Analysis for Validating Interrelationships of Combined Medication of Compound Kushen Injection in Treating Colon Carcinoma: A Hospital Information System-Based Real-World Study
por: Yang, Huisheng, et al.
Publicado: (2018)

Efficacy and safety of compound Kushen injection combined with chemotherapy on postoperative Patients with breast cancer: A meta-analysis of randomized controlled trials
por: Ao, Man, et al.
Publicado: (2019)

Compound Kushen Injection as an Adjunctive Therapy for the Treatment of Non-Small-Cell Lung Cancer: A Meta-Analysis of Randomized Controlled Trials
por: Pu, Liu, et al.
Publicado: (2019)

A New Strategy for Identifying Mechanisms of Drug-drug Interaction Using Transcriptome Analysis: Compound Kushen Injection as a Proof of Principle
por: Shen, Hanyuan, et al.
Publicado: (2019)

Efficacy of Compound Kushen Injection in Combination with Induction Chemotherapy for Treating Adult Patients Newly Diagnosed with Acute Leukemia
por: Tu, Honglei, et al.
Publicado: (2016)

Network Pharmacology-Based Study on the Molecular Biological Mechanism of Action for Compound Kushen Injection in Anti-Cancer Effect
por: He, Ruirong, et al.
Publicado: (2020)

Compound Kushen injection inhibits EMT of gastric cancer cells via the PI3K/AKT pathway
por: Li, Luo, et al.
Publicado: (2022)

Exploring the nucleotide molecular mechanism of compound kushen injection for lung adenocarcinoma based on network pharmacology and molecular docking
por: Ye, Zhangpeng, et al.
Publicado: (2022)

High Throughput Transcriptome Data Analysis and Computational Verification Reveal Immunotherapy Biomarkers of Compound Kushen Injection for Treating Triple-Negative Breast Cancer
por: Liu, Xinkui, et al.
Publicado: (2021)

Clinical Effectiveness and Safety of Chinese Herbal Medicine Compound Kushen Injection as an Add-On Treatment for Breast Cancer: A Systematic Review and Meta-Analysis
por: Lai, Bao-Yong, et al.
Publicado: (2022)

Compound kushen injection suppresses human acute myeloid leukaemia by regulating the Prdxs/ROS/Trx1 signalling pathway
por: Jin, Yanxia, et al.
Publicado: (2018)

A Bioinformatics Research on Novel Mechanism of Compound Kushen Injection for Treating Breast Cancer by Network Pharmacology and Molecular Docking Verification
por: Liu, Shuyu, et al.
Publicado: (2020)

Compound kushen injection relieves tumor-associated macrophage-mediated immunosuppression through TNFR1 and sensitizes hepatocellular carcinoma to sorafenib
por: Yang, Yang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_co2ucndq6a9i9qllds2kjqdd4a