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(95g)Tc and (96g)Tc as alternatives to medical radioisotope (99m)Tc

We studied (95g)Tc and (96g)Tc as alternatives to the medical radioisotope (99m)Tc. (96g)Tc ((95g)Tc) can be produced by (p, n) reactions on an enriched (96)Mo ((95)Mo) target with a proton beam provided by a compact accelerator such as a medical cyclotron that generate radioisotopes for positron em...

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Detalles Bibliográficos
Autores principales: Hayakawa, Takehito, Hatsukawa, Yuichi, Tanimori, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766687/
https://www.ncbi.nlm.nih.gov/pubmed/29349358
http://dx.doi.org/10.1016/j.heliyon.2017.e00497
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author Hayakawa, Takehito
Hatsukawa, Yuichi
Tanimori, Toru
author_facet Hayakawa, Takehito
Hatsukawa, Yuichi
Tanimori, Toru
author_sort Hayakawa, Takehito
collection PubMed
description We studied (95g)Tc and (96g)Tc as alternatives to the medical radioisotope (99m)Tc. (96g)Tc ((95g)Tc) can be produced by (p, n) reactions on an enriched (96)Mo ((95)Mo) target with a proton beam provided by a compact accelerator such as a medical cyclotron that generate radioisotopes for positron emission tomography (PET). The γ-rays are measured with an electron-tracking Compton camera (ETCC). We calculated the relative intensities of the γ-rays from (95g)Tc and (96g)Tc. The calculated γ-ray intensity of a (96g)Tc ((95g)Tc) nucleus is as high as 63% (70%) of that of a (99m)Tc nucleus. We also calculated the patient radiation doses of (95g)Tc and (96g)Tc, which were larger than that of (99m)Tc by a factor of 2–3 based on the applied assumptions. A medical PET cyclotron which can provide proton beams with energies of 11–12 MeV and a current of 100 μA can produce 12 GBq (39 GBq) of (96g)Tc ((95g)Tc) for operation time of 8 h, which can be used for 240 (200) diagnostic scans.
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spelling pubmed-57666872018-01-18 (95g)Tc and (96g)Tc as alternatives to medical radioisotope (99m)Tc Hayakawa, Takehito Hatsukawa, Yuichi Tanimori, Toru Heliyon Article We studied (95g)Tc and (96g)Tc as alternatives to the medical radioisotope (99m)Tc. (96g)Tc ((95g)Tc) can be produced by (p, n) reactions on an enriched (96)Mo ((95)Mo) target with a proton beam provided by a compact accelerator such as a medical cyclotron that generate radioisotopes for positron emission tomography (PET). The γ-rays are measured with an electron-tracking Compton camera (ETCC). We calculated the relative intensities of the γ-rays from (95g)Tc and (96g)Tc. The calculated γ-ray intensity of a (96g)Tc ((95g)Tc) nucleus is as high as 63% (70%) of that of a (99m)Tc nucleus. We also calculated the patient radiation doses of (95g)Tc and (96g)Tc, which were larger than that of (99m)Tc by a factor of 2–3 based on the applied assumptions. A medical PET cyclotron which can provide proton beams with energies of 11–12 MeV and a current of 100 μA can produce 12 GBq (39 GBq) of (96g)Tc ((95g)Tc) for operation time of 8 h, which can be used for 240 (200) diagnostic scans. Elsevier 2018-01-08 /pmc/articles/PMC5766687/ /pubmed/29349358 http://dx.doi.org/10.1016/j.heliyon.2017.e00497 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Hayakawa, Takehito
Hatsukawa, Yuichi
Tanimori, Toru
(95g)Tc and (96g)Tc as alternatives to medical radioisotope (99m)Tc
title (95g)Tc and (96g)Tc as alternatives to medical radioisotope (99m)Tc
title_full (95g)Tc and (96g)Tc as alternatives to medical radioisotope (99m)Tc
title_fullStr (95g)Tc and (96g)Tc as alternatives to medical radioisotope (99m)Tc
title_full_unstemmed (95g)Tc and (96g)Tc as alternatives to medical radioisotope (99m)Tc
title_short (95g)Tc and (96g)Tc as alternatives to medical radioisotope (99m)Tc
title_sort (95g)tc and (96g)tc as alternatives to medical radioisotope (99m)tc
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766687/
https://www.ncbi.nlm.nih.gov/pubmed/29349358
http://dx.doi.org/10.1016/j.heliyon.2017.e00497
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