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The temporal behavior and consistency of bipolar atrial electrograms in human persistent atrial fibrillation
The unstable temporal behavior of atrial electrical activity during persistent atrial fibrillation (persAF) might influence ablation target identification, which could explain the conflicting persAF ablation outcomes in previous studies. We sought to investigate the temporal behavior and consistency...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766733/ https://www.ncbi.nlm.nih.gov/pubmed/28674778 http://dx.doi.org/10.1007/s11517-017-1667-1 |
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author | Almeida, Tiago P. Chu, Gavin S. Bell, Michael J. Li, Xin Salinet, João L. Dastagir, Nawshin Tuan, Jiun H. Stafford, Peter J. André Ng, G. Schlindwein, Fernando S. |
author_facet | Almeida, Tiago P. Chu, Gavin S. Bell, Michael J. Li, Xin Salinet, João L. Dastagir, Nawshin Tuan, Jiun H. Stafford, Peter J. André Ng, G. Schlindwein, Fernando S. |
author_sort | Almeida, Tiago P. |
collection | PubMed |
description | The unstable temporal behavior of atrial electrical activity during persistent atrial fibrillation (persAF) might influence ablation target identification, which could explain the conflicting persAF ablation outcomes in previous studies. We sought to investigate the temporal behavior and consistency of atrial electrogram (AEG) fractionation using different segment lengths. Seven hundred ninety-seven bipolar AEGs were collected with three segment lengths (2.5, 5,and 8 s) from 18 patients undergoing persAF ablation. The AEGs with 8-s duration were divided into three 2.5-s consecutive segments. AEG fractionation classification was applied off-line to all cases following the CARTO criteria; 43% of the AEGs remained fractionated for the three consecutive AEG segments, while nearly 30% were temporally unstable. AEG classification within the consecutive segments had moderate correlation (segment 1 vs 2: Spearman’s correlation ρ = 0.74, kappa score κ = 0.62; segment 1 vs 3: ρ = 0.726, κ = 0.62; segment 2 vs 3: ρ = 0.75, κ = 0.68). AEG classifications were more similar between AEGs with 5 and 8 s (ρ = 0.96, κ = 0.87) than 2.5 versus 5 s (ρ = 0.93, κ = 0.84) and 2.5 versus 8 s (ρ = 0.90, κ = 0.78). Our results show that the CARTO criteria should be revisited and consider recording duration longer than 2.5 s for consistent ablation target identification in persAF. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11517-017-1667-1) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5766733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-57667332018-01-25 The temporal behavior and consistency of bipolar atrial electrograms in human persistent atrial fibrillation Almeida, Tiago P. Chu, Gavin S. Bell, Michael J. Li, Xin Salinet, João L. Dastagir, Nawshin Tuan, Jiun H. Stafford, Peter J. André Ng, G. Schlindwein, Fernando S. Med Biol Eng Comput Original Article The unstable temporal behavior of atrial electrical activity during persistent atrial fibrillation (persAF) might influence ablation target identification, which could explain the conflicting persAF ablation outcomes in previous studies. We sought to investigate the temporal behavior and consistency of atrial electrogram (AEG) fractionation using different segment lengths. Seven hundred ninety-seven bipolar AEGs were collected with three segment lengths (2.5, 5,and 8 s) from 18 patients undergoing persAF ablation. The AEGs with 8-s duration were divided into three 2.5-s consecutive segments. AEG fractionation classification was applied off-line to all cases following the CARTO criteria; 43% of the AEGs remained fractionated for the three consecutive AEG segments, while nearly 30% were temporally unstable. AEG classification within the consecutive segments had moderate correlation (segment 1 vs 2: Spearman’s correlation ρ = 0.74, kappa score κ = 0.62; segment 1 vs 3: ρ = 0.726, κ = 0.62; segment 2 vs 3: ρ = 0.75, κ = 0.68). AEG classifications were more similar between AEGs with 5 and 8 s (ρ = 0.96, κ = 0.87) than 2.5 versus 5 s (ρ = 0.93, κ = 0.84) and 2.5 versus 8 s (ρ = 0.90, κ = 0.78). Our results show that the CARTO criteria should be revisited and consider recording duration longer than 2.5 s for consistent ablation target identification in persAF. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11517-017-1667-1) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2017-07-03 2018 /pmc/articles/PMC5766733/ /pubmed/28674778 http://dx.doi.org/10.1007/s11517-017-1667-1 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Almeida, Tiago P. Chu, Gavin S. Bell, Michael J. Li, Xin Salinet, João L. Dastagir, Nawshin Tuan, Jiun H. Stafford, Peter J. André Ng, G. Schlindwein, Fernando S. The temporal behavior and consistency of bipolar atrial electrograms in human persistent atrial fibrillation |
title | The temporal behavior and consistency of bipolar atrial electrograms in human persistent atrial fibrillation |
title_full | The temporal behavior and consistency of bipolar atrial electrograms in human persistent atrial fibrillation |
title_fullStr | The temporal behavior and consistency of bipolar atrial electrograms in human persistent atrial fibrillation |
title_full_unstemmed | The temporal behavior and consistency of bipolar atrial electrograms in human persistent atrial fibrillation |
title_short | The temporal behavior and consistency of bipolar atrial electrograms in human persistent atrial fibrillation |
title_sort | temporal behavior and consistency of bipolar atrial electrograms in human persistent atrial fibrillation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766733/ https://www.ncbi.nlm.nih.gov/pubmed/28674778 http://dx.doi.org/10.1007/s11517-017-1667-1 |
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