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Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML

Bone marrow vascular niches sustain hematopoietic stem cells (HSCs) and are drastically remodeled in leukemia to support pathological functions. Acute myeloid leukemia (AML) cells produce angiogenic factors, which likely contribute to this remodeling, but anti-angiogenic therapies do not improve AML...

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Detalles Bibliográficos
Autores principales:	Duarte, Delfim, Hawkins, Edwin D., Akinduro, Olufolake, Ang, Heather, De Filippo, Katia, Kong, Isabella Y., Haltalli, Myriam, Ruivo, Nicola, Straszkowski, Lenny, Vervoort, Stephin J., McLean, Catriona, Weber, Tom S., Khorshed, Reema, Pirillo, Chiara, Wei, Andrew, Ramasamy, Saravana K., Kusumbe, Anjali P., Duffy, Ken, Adams, Ralf H., Purton, Louise E., Carlin, Leo M., Lo Celso, Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766835/ https://www.ncbi.nlm.nih.gov/pubmed/29276143 http://dx.doi.org/10.1016/j.stem.2017.11.006

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