Cargando…

Production of eicosapentaenoic acid by application of a delta-6 desaturase with the highest ALA catalytic activity in algae

ABSTRACT: Dunaliella salina is a unicellular green alga with a high α-linolenic acid (ALA) level, but a low eicosapentaenoic acid (EPA) level. In a previous analysis of the catalytic activity of delta 6 fatty acid desaturase (FADS6) from various species, FADS6 from Thalassiosira pseudonana (TpFADS6)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Haisu, Luo, Xue, Wu, Rina, Yue, Xiqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766975/ https://www.ncbi.nlm.nih.gov/pubmed/29331150 http://dx.doi.org/10.1186/s12934-018-0857-3

Ejemplares similares

Application of a delta-6 desaturase with α-linolenic acid preference on eicosapentaenoic acid production in Mortierella alpina
por: Shi, Haisu, et al.
Publicado: (2016)

Δ12 fatty acid desaturase gene from Geotrichum candidum in cheese: molecular cloning and functional characterization
por: Luo, Xue, et al.
Publicado: (2018)

Application of a ω-3 Desaturase with an Arachidonic Acid Preference to Eicosapentaenoic Acid Production in Mortierella alpina
por: Ge, Chengfeng, et al.
Publicado: (2018)

Characterization of an Omega-3 Desaturase From Phytophthora parasitica and Application for Eicosapentaenoic Acid Production in Mortierella alpina
por: Tang, Xin, et al.
Publicado: (2018)

Improved γ-linolenic acid production in Mucor circinelloides by homologous overexpressing of delta-12 and delta-6 desaturases
por: Zhang, Yao, et al.
Publicado: (2017)

Delta-6-desaturase inhibitor enhances radiation therapy in glioblastoma in vitro and in vivo
por: Wang, Jie, et al.
Publicado: (2018)

Homologous and Heterologous Expression of Delta(12)-Desaturase in Mucor circinelloides Enhanced the Production of Linolenic Acid
por: Yang, Junhuan, et al.
Publicado: (2022)

Delta-6-desaturase gene polymorphism is associated with lipoprotein oxidation in vitro
por: Solakivi, Tiina, et al.
Publicado: (2013)

Inhibiting Delta-6 Desaturase Activity Suppresses Tumor Growth in Mice
por: He, Chengwei, et al.
Publicado: (2012)

Plastidial acyl carrier protein Δ9‐desaturase modulates eicosapentaenoic acid biosynthesis and triacylglycerol accumulation in Phaeodactylum tricornutum
por: Smith, Richard, et al.
Publicado: (2021)

Intestinal delta-6-desaturase activity determines host range for Toxoplasma sexual reproduction
por: Martorelli Di Genova, Bruno, et al.
Publicado: (2019)

Delta-6-desaturase (FADS2) inhibition and omega-3 fatty acids in skeletal muscle protein turnover
por: Brown, Katie M., et al.
Publicado: (2019)

Molecular mechanism of interaction between fatty acid delta 6 desaturase and acyl-CoA by computational prediction
por: Cui, Jie, et al.
Publicado: (2022)

Delta-9 fatty acid desaturase mutants display increased body size
por: Clark, James F., et al.
Publicado: (2018)

Transgenic expression of delta-6 and delta-15 fatty acid desaturases enhances omega-3 polyunsaturated fatty acid accumulation in Synechocystis sp. PCC6803
por: Chen, Gao, et al.
Publicado: (2014)

A regulatory role for porphobilinogen deaminase (PBGD) in delta-aminolaevulinic acid (delta-ALA)-induced photosensitization?
por: Gibson, S. L., et al.
Publicado: (1998)

Dual expression of transgenic delta-5 and delta-6 desaturase in tilapia alters gut microbiota and enhances resistance to Vibrio vulnificus infection
por: Chiang, Keng-Yu, et al.
Publicado: (2020)

The yin and yang of 15-lipoxygenase-1 and delta-desaturases: Dietary omega-6 linoleic acid metabolic pathway in prostate
por: Kelavkar, Uddhav, et al.
Publicado: (2006)

Delta-6 desaturase (Fads2) deficiency alters triacylglycerol/fatty acid cycling in murine white adipose tissue
por: Wang, Chenxuan, et al.
Publicado: (2023)

Delta-5-desaturase: A novel therapeutic target for cancer management
por: Pang, Lizhi, et al.
Publicado: (2021)

Association of Delta-6-Desaturase Expression with Aggressiveness of Cancer, Diabetes Mellitus, and Multiple Sclerosis: A Narrative Review
por: Arshad, Zhila, et al.
Publicado: (2019)

Fatty acid profiles and Delta9 desaturase (stearoyl-CoA desaturase; SCD 1) expression in adipose tissue surrounding benign and malignant breast tumors
por: Sefidabi, Reyhaneh, et al.
Publicado: (2023)

Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse
por: Monteiro, Jessica, et al.
Publicado: (2012)

NSCLC Cells Resistance to PI3K/mTOR Inhibitors Is Mediated by Delta-6 Fatty Acid Desaturase (FADS2)
por: Colombo, Marika, et al.
Publicado: (2022)

Relationships of Fatty Acids, Delta-5 Desaturase Activity, and Lipid Profiles in Men with Acute Coronary Syndrome
por: Arai, Ken, et al.
Publicado: (2020)

The sphingolipid biosynthetic enzyme Sphingolipid delta8 desaturase is important for chilling resistance of tomato
por: Zhou, Ying, et al.
Publicado: (2016)

Comparative transcriptome analysis reveals ectopic delta-5 and delta-6 desaturases enhance protective gene expression upon Vibrio vulnificus challenge in Tilapia (Oreochromis niloticus)
por: Tu, Pin-Yang, et al.
Publicado: (2021)

Increased Expression of Hepatic Stearoyl-CoA Desaturase (SCD)-1 and Depletion of Eicosapentaenoic Acid (EPA) Content following Cytotoxic Cancer Therapy Are Reversed by Dietary Fish Oil
por: Monirujjaman, Md, et al.
Publicado: (2023)

Integration of Seismic and Petrophysics to Characterize Reservoirs in “ALA” Oil Field, Niger Delta
por: Alao, P. A., et al.
Publicado: (2013)

Effects of Temperature and Salt Stress on the Expression of delta-12 Fatty Acid Desaturase Genes and Fatty Acid Compositions in Safflower
por: Li, Dandan, et al.
Publicado: (2023)

Analysis of Delta(9) fatty acid desaturase gene family and their role in oleic acid accumulation in Carya cathayensis kernel
por: Si, Xiaolin, et al.
Publicado: (2023)

Simultaneous overexpression of ∆6-, ∆12- and ∆9-desaturases enhanced the production of γ-linolenic acid in Mucor circinelloides WJ11
por: Wang, Xiuwen, et al.
Publicado: (2022)

Effects of Eicosapentaenoic Acid on Arterial Calcification
por: Saito, Yukihiro, et al.
Publicado: (2020)

Intracellular Targeting Signals and Lipid Specificity Determinants of the ALA/ALIS P(4)-ATPase Complex Reside in the Catalytic ALA α-Subunit
por: López-Marqués, Rosa L., et al.
Publicado: (2010)

Ethnicity, sex, FADS genetic variation, and hormonal contraceptive use influence delta-5- and delta-6-desaturase indices and plasma docosahexaenoic acid concentration in young Canadian adults: a cross-sectional study
por: Abdelmagid, Salma A, et al.
Publicado: (2015)

The ALA5/ALA6/ALA7 repeat polymorphisms of the glutathione peroxidase‐1 ( GPx1 ) gene and autism spectrum disorder
por: Carducci, Federica, et al.
Publicado: (2022)

Modification of the photodynamic action of delta-aminolaevulinic acid (ALA) on rat pancreatoma cells by mitochondrial benzodiazepine receptor ligands.
por: Ratcliffe, S. L., et al.
Publicado: (1995)

Characterization of fatty acid desaturases reveals stress-induced synthesis of C18 unsaturated fatty acids enriched in triacylglycerol in the oleaginous alga Chromochloris zofingiensis
por: Wu, Tao, et al.
Publicado: (2021)

Distinguishing Health Benefits of Eicosapentaenoic and Docosahexaenoic Acids
por: Russell, Fraser D., et al.
Publicado: (2012)

Saturated Fatty Acid Intake Is Associated With Increased Inflammation, Conversion of Kynurenine to Tryptophan, and Delta-9 Desaturase Activity in Healthy Humans
por: Berg, Jade, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_8l02ikrsvfj03hjsksph644dbr