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Targeting ectodysplasin promotor by CRISPR/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells
BACKGROUND: Patients with a deep burn injury are characterized by losing the function of perspiration and being unable to regenerate the sweat glands. Because of their easy accession, multipotency, and lower immunogenicity, bone marrow-derived mesenchymal stem cells (BM-MSCs) represent as an ideal b...
Autores principales: | Sun, Sujing, Xiao, Jun, Huo, Jiahui, Geng, Zhijun, Ma, Kui, Sun, Xiaoyan, Fu, Xiaobing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766979/ https://www.ncbi.nlm.nih.gov/pubmed/29329593 http://dx.doi.org/10.1186/s13287-017-0758-0 |
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