Targeting ectodysplasin promotor by CRISPR/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells

BACKGROUND: Patients with a deep burn injury are characterized by losing the function of perspiration and being unable to regenerate the sweat glands. Because of their easy accession, multipotency, and lower immunogenicity, bone marrow-derived mesenchymal stem cells (BM-MSCs) represent as an ideal b...

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Detalles Bibliográficos
Autores principales: Sun, Sujing, Xiao, Jun, Huo, Jiahui, Geng, Zhijun, Ma, Kui, Sun, Xiaoyan, Fu, Xiaobing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766979/
https://www.ncbi.nlm.nih.gov/pubmed/29329593
http://dx.doi.org/10.1186/s13287-017-0758-0

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