Cargando…

Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import

BACKGROUND: Combination antiretroviral therapy efficiently suppresses HIV replication in infected patients, transforming HIV/AIDS into a chronic disease. Viral resistance does develop however, especially under suboptimal treatment conditions such as poor adherence. As a consequence, continued explor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Demeulemeester, Jonas, Blokken, Jolien, De Houwer, Stéphanie, Dirix, Lieve, Klaassen, Hugo, Marchand, Arnaud, Chaltin, Patrick, Christ, Frauke, Debyser, Zeger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767004/ https://www.ncbi.nlm.nih.gov/pubmed/29329553 http://dx.doi.org/10.1186/s12977-018-0389-2

Ejemplares similares

Interplay between HIV Entry and Transportin-SR2 Dependency
por: Thys, Wannes, et al.
Publicado: (2011)

Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry
por: Borrenberghs, Doortje, et al.
Publicado: (2016)

Role of Transportin-SR2 in HIV-1 Nuclear Import
por: Tabasi, Maryam, et al.
Publicado: (2021)

CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import
por: Janssens, Julie, et al.
Publicado: (2021)

Cellular Cofactors of Lentiviral Integrase: From Target Validation to Drug Discovery
por: Taltynov, Oliver, et al.
Publicado: (2012)

A Symmetric Region of the HIV-1 Integrase Dimerization Interface Is Essential for Viral Replication
por: Serrao, Erik, et al.
Publicado: (2012)

2-Hydroxyisoquinoline-1,3(2H, 4H)diones (HQDs), novel inhibitors of the HIV integrase catalytic activity with a high barrier to resistance
por: Christ, Frauke, et al.
Publicado: (2013)

Transportin-SR, a Nuclear Import Receptor for SR Proteins
por: Kataoka, Naoyuki, et al.
Publicado: (1999)

LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV
por: Vranckx, Lenard S., et al.
Publicado: (2016)

HIV Virions as Nanoscopic Test Tubes for Probing Oligomerization of the Integrase Enzyme
por: Borrenberghs, Doortje, et al.
Publicado: (2014)

Post-mitotic BET-induced reshaping of integrase quaternary structure supports wild-type MLV integration
por: Borrenberghs, Doortje, et al.
Publicado: (2019)

LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions
por: Desimmie, Belete Ayele, et al.
Publicado: (2013)

Correction to: LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions
por: Desimmie, Belete Ayele, et al.
Publicado: (2020)

LEDGINs, a novel class of antivirals targeting HIV integrase during integration and assembly
por: Debyser, Zeger
Publicado: (2013)

The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection
por: Rodríguez-Mora, Sara, et al.
Publicado: (2019)

Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection
por: Debyser, Zeger, et al.
Publicado: (2018)

Transportin-SR Is Required for Proper Splicing of Resistance Genes and Plant Immunity
por: Xu, Shaohua, et al.
Publicado: (2011)

Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras
por: Vranckx, Lenard S., et al.
Publicado: (2016)

Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection
por: Demeulemeester, Jonas, et al.
Publicado: (2015)

LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs
por: Schrijvers, Rik, et al.
Publicado: (2012)

Correction: LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs
por: Schrijvers, Rik, et al.
Publicado: (2020)

Towards a Functional Cure of HIV-1: Insight Into the Chromatin Landscape of the Provirus
por: Janssens, Julie, et al.
Publicado: (2021)

Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV—Based Vectors and for a Cure for HIV-1 Infection
por: Pellaers, Eline, et al.
Publicado: (2022)

Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach
por: Sirous, Hajar, et al.
Publicado: (2019)

Insight into HIV-2 latency may disclose strategies for a cure for HIV-1 infection
por: Saleh, Suha, et al.
Publicado: (2017)

Synthesis and Anti-HIV Profile of a Novel Tetrahydroindazolylbenzamide Derivative Obtained by Oxazolone Chemistry
por: Scala, Angela, et al.
Publicado: (2018)

Transportin-mediated Nuclear Import of Heterogeneous Nuclear RNP Proteins
por: Siomi, Mikiko C., et al.
Publicado: (1997)

PB1704: LEDGF/P75 ASSOCIATED WITH CHEMORESISTANCE IN MIXED-LINEAGE LEUKEMIA
por: Akele, Muluembet, et al.
Publicado: (2023)

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles
por: Desimmie, Belete Ayele, et al.
Publicado: (2015)

Correction to: HIV-1 IN/Pol recruits LEDGF/p75 into viral particles
por: Desimmie, Belete Ayele, et al.
Publicado: (2020)

Pigment Epithelium-Derived Factor (PEDF) Interacts with Transportin SR2, and Active Nuclear Import Is Facilitated by a Novel Nuclear Localization Motif
por: Anguissola, Sergio, et al.
Publicado: (2011)

Transportin-1: A Nuclear Import Receptor with Moonlighting Functions
por: Mboukou, Allegra, et al.
Publicado: (2021)

Y-box-binding protein 1 supports the early and late steps of HIV replication
por: Weydert, Caroline, et al.
Publicado: (2018)

Correction: Y-box-binding protein 1 supports the early and late steps of HIV replication
por: Weydert, Caroline, et al.
Publicado: (2020)

A Role for Transportin in the Nuclear Import of Adenovirus Core Proteins and DNA
por: Hindley, Clemence E, et al.
Publicado: (2007)

Tumor suppressor BAP1 nuclear import is governed by transportin-1
por: Yang, Tzu-Jing, et al.
Publicado: (2022)

Transportin HIV-1 by tRNAin and CAr
por: Zhou, Lihong, et al.
Publicado: (2011)

Distinct mutations in importin-β family nucleocytoplasmic transport receptors transportin-SR and importin-13 affect specific cargo binding
por: Kimura, Makoto, et al.
Publicado: (2021)

Block-And-Lock Strategies to Cure HIV Infection
por: Vansant, Gerlinde, et al.
Publicado: (2020)

Transportin-3 Facilitates Uncoating of Influenza A Virus
por: Zou, Jiahui, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ttrasql2pbd4e2qddh162be6gk