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The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4(+) T cells

BACKGROUND: The HIV-1 accessory proteins Nef and Vpu alter cell surface levels of multiple host proteins to modify the immune response and increase viral persistence. Nef and Vpu can downregulate cell surface levels of the co-stimulatory molecule CD28, however the mechanism of this function has not...

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Detalles Bibliográficos
Autores principales:	Pawlak, Emily N., Dirk, Brennan S., Jacob, Rajesh Abraham, Johnson, Aaron L., Dikeakos, Jimmy D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767034/ https://www.ncbi.nlm.nih.gov/pubmed/29329537 http://dx.doi.org/10.1186/s12977-018-0388-3

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