Cargando…
An exploratory study of adolescent response to fluoxetine using psychological and biological predictors
BACKGROUND: Not enough is known about predicting therapeutic response to serotonin-specific reuptake inhibitors, and specifically to fluoxetine. This exploratory study used psychological and biological markers for (retrospective) prediction of treatment-response to fluoxetine in depressed and/or anx...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767083/ https://www.ncbi.nlm.nih.gov/pubmed/29340244 http://dx.doi.org/10.7717/peerj.4240 |
_version_ | 1783292476446998528 |
---|---|
author | Zohar, Ada H. Eilat, Tamar Amitai, Maya Taler, Michal Bari, Romi Chen, Alon Apter, Alan Weizman, Avraham Fennig, Silvana |
author_facet | Zohar, Ada H. Eilat, Tamar Amitai, Maya Taler, Michal Bari, Romi Chen, Alon Apter, Alan Weizman, Avraham Fennig, Silvana |
author_sort | Zohar, Ada H. |
collection | PubMed |
description | BACKGROUND: Not enough is known about predicting therapeutic response to serotonin-specific reuptake inhibitors, and specifically to fluoxetine. This exploratory study used psychological and biological markers for (retrospective) prediction of treatment-response to fluoxetine in depressed and/or anxious adolescents. METHODS: Forty-one consecutive adolescent outpatients with a primary diagnosis of severe affective and/or anxiety disorders were assessed and treated with an open-label 8-week trial of fluoxetine. Type D personality was assessed with the 14-item questionnaire, the DS14. In addition, TNFα, IL-6, and IL-1b were measured pre- and post-treatment. RESULTS: There was an elevation of Type D personality in patients, compared to the adolescent population rate. Post-treatment, 44% of patients were classified as non-responders; the relative risk of non-response for Type D personality patients was 2.8. Binary logistic regression predicting response vs. non-response showed a contribution of initial TNFα levels as well as Type D personality to non-response. CONCLUSIONS: In this exploratory study, the most significant contributor to non-response was Type D personality. However, the measurement of Type D was not prospective, and thus may be confounded with psychiatric morbidity. The measurement of personality in psychiatric settings may contribute to the understanding of treatment response and have clinical utility. |
format | Online Article Text |
id | pubmed-5767083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57670832018-01-16 An exploratory study of adolescent response to fluoxetine using psychological and biological predictors Zohar, Ada H. Eilat, Tamar Amitai, Maya Taler, Michal Bari, Romi Chen, Alon Apter, Alan Weizman, Avraham Fennig, Silvana PeerJ Psychiatry and Psychology BACKGROUND: Not enough is known about predicting therapeutic response to serotonin-specific reuptake inhibitors, and specifically to fluoxetine. This exploratory study used psychological and biological markers for (retrospective) prediction of treatment-response to fluoxetine in depressed and/or anxious adolescents. METHODS: Forty-one consecutive adolescent outpatients with a primary diagnosis of severe affective and/or anxiety disorders were assessed and treated with an open-label 8-week trial of fluoxetine. Type D personality was assessed with the 14-item questionnaire, the DS14. In addition, TNFα, IL-6, and IL-1b were measured pre- and post-treatment. RESULTS: There was an elevation of Type D personality in patients, compared to the adolescent population rate. Post-treatment, 44% of patients were classified as non-responders; the relative risk of non-response for Type D personality patients was 2.8. Binary logistic regression predicting response vs. non-response showed a contribution of initial TNFα levels as well as Type D personality to non-response. CONCLUSIONS: In this exploratory study, the most significant contributor to non-response was Type D personality. However, the measurement of Type D was not prospective, and thus may be confounded with psychiatric morbidity. The measurement of personality in psychiatric settings may contribute to the understanding of treatment response and have clinical utility. PeerJ Inc. 2018-01-10 /pmc/articles/PMC5767083/ /pubmed/29340244 http://dx.doi.org/10.7717/peerj.4240 Text en ©2018 Zohar et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Psychiatry and Psychology Zohar, Ada H. Eilat, Tamar Amitai, Maya Taler, Michal Bari, Romi Chen, Alon Apter, Alan Weizman, Avraham Fennig, Silvana An exploratory study of adolescent response to fluoxetine using psychological and biological predictors |
title | An exploratory study of adolescent response to fluoxetine using psychological and biological predictors |
title_full | An exploratory study of adolescent response to fluoxetine using psychological and biological predictors |
title_fullStr | An exploratory study of adolescent response to fluoxetine using psychological and biological predictors |
title_full_unstemmed | An exploratory study of adolescent response to fluoxetine using psychological and biological predictors |
title_short | An exploratory study of adolescent response to fluoxetine using psychological and biological predictors |
title_sort | exploratory study of adolescent response to fluoxetine using psychological and biological predictors |
topic | Psychiatry and Psychology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767083/ https://www.ncbi.nlm.nih.gov/pubmed/29340244 http://dx.doi.org/10.7717/peerj.4240 |
work_keys_str_mv | AT zoharadah anexploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT eilattamar anexploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT amitaimaya anexploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT talermichal anexploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT bariromi anexploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT chenalon anexploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT apteralan anexploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT weizmanavraham anexploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT fennigsilvana anexploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT zoharadah exploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT eilattamar exploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT amitaimaya exploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT talermichal exploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT bariromi exploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT chenalon exploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT apteralan exploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT weizmanavraham exploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors AT fennigsilvana exploratorystudyofadolescentresponsetofluoxetineusingpsychologicalandbiologicalpredictors |