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Altered intrinsic brain activities in patients with acute eye pain using amplitude of low-frequency fluctuation: a resting-state fMRI study

OBJECTIVE: Many previous studies have reported that pain symptoms can lead to significant brain function and anatomical changes, whereas the intrinsic brain activity changes in acute eye pain (EP) patients remain unknown. Using the amplitude of low-frequency fluctuation (ALFF) method, this study aim...

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Autores principales: Pan, Zhi-Ming, Li, Hai-Jun, Bao, Jing, Jiang, Nan, Yuan, Qing, Freeberg, Shelby, Zhu, Pei-Wen, Ye, Lei, Ma, Ming-Yang, Huang, Xin, Shao, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767092/
https://www.ncbi.nlm.nih.gov/pubmed/29386898
http://dx.doi.org/10.2147/NDT.S150051
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author Pan, Zhi-Ming
Li, Hai-Jun
Bao, Jing
Jiang, Nan
Yuan, Qing
Freeberg, Shelby
Zhu, Pei-Wen
Ye, Lei
Ma, Ming-Yang
Huang, Xin
Shao, Yi
author_facet Pan, Zhi-Ming
Li, Hai-Jun
Bao, Jing
Jiang, Nan
Yuan, Qing
Freeberg, Shelby
Zhu, Pei-Wen
Ye, Lei
Ma, Ming-Yang
Huang, Xin
Shao, Yi
author_sort Pan, Zhi-Ming
collection PubMed
description OBJECTIVE: Many previous studies have reported that pain symptoms can lead to significant brain function and anatomical changes, whereas the intrinsic brain activity changes in acute eye pain (EP) patients remain unknown. Using the amplitude of low-frequency fluctuation (ALFF) method, this study aimed to evaluate the spontaneous brain activity alterations and their relationships with clinical features in acute EP patients. PARTICIPANTS AND METHODS: A total of 20 patients with EP (15 males and 5 females) and 20 healthy controls (HCs; 15 males and 5 females) closely matched in age, sex, and education underwent resting-state functional magnetic resonance imaging scans. The ALFF method was applied to assess spontaneous brain activity changes. The ALFF values of the EP patients were distinguished from those of the HCs using a receiver operating characteristic curve. Pearson’s correlation analysis was used to investigate the relationships between the mean ALFF signal values from many brain regions and the clinical features in EP patients. RESULTS: Compared with the HCs, acute EP patients had significantly lower ALFF in the left and right precentral/postcentral gyrus and left precuneus. In contrast, acute EP patients showed higher ALFF values in the right and left parahippocampal gyri and left caudate. However, no relationship was observed between the mean ALFF signal values from the different areas and clinical manifestations in the acute EP patients. CONCLUSION: We demonstrated that acute EP patients showed abnormal intrinsic brain activities in the precentral/postcentral gyrus and limbic system, which might provide useful information for explaining neural mechanisms in EP patients.
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spelling pubmed-57670922018-01-31 Altered intrinsic brain activities in patients with acute eye pain using amplitude of low-frequency fluctuation: a resting-state fMRI study Pan, Zhi-Ming Li, Hai-Jun Bao, Jing Jiang, Nan Yuan, Qing Freeberg, Shelby Zhu, Pei-Wen Ye, Lei Ma, Ming-Yang Huang, Xin Shao, Yi Neuropsychiatr Dis Treat Original Research OBJECTIVE: Many previous studies have reported that pain symptoms can lead to significant brain function and anatomical changes, whereas the intrinsic brain activity changes in acute eye pain (EP) patients remain unknown. Using the amplitude of low-frequency fluctuation (ALFF) method, this study aimed to evaluate the spontaneous brain activity alterations and their relationships with clinical features in acute EP patients. PARTICIPANTS AND METHODS: A total of 20 patients with EP (15 males and 5 females) and 20 healthy controls (HCs; 15 males and 5 females) closely matched in age, sex, and education underwent resting-state functional magnetic resonance imaging scans. The ALFF method was applied to assess spontaneous brain activity changes. The ALFF values of the EP patients were distinguished from those of the HCs using a receiver operating characteristic curve. Pearson’s correlation analysis was used to investigate the relationships between the mean ALFF signal values from many brain regions and the clinical features in EP patients. RESULTS: Compared with the HCs, acute EP patients had significantly lower ALFF in the left and right precentral/postcentral gyrus and left precuneus. In contrast, acute EP patients showed higher ALFF values in the right and left parahippocampal gyri and left caudate. However, no relationship was observed between the mean ALFF signal values from the different areas and clinical manifestations in the acute EP patients. CONCLUSION: We demonstrated that acute EP patients showed abnormal intrinsic brain activities in the precentral/postcentral gyrus and limbic system, which might provide useful information for explaining neural mechanisms in EP patients. Dove Medical Press 2018-01-09 /pmc/articles/PMC5767092/ /pubmed/29386898 http://dx.doi.org/10.2147/NDT.S150051 Text en © 2018 Pan et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Pan, Zhi-Ming
Li, Hai-Jun
Bao, Jing
Jiang, Nan
Yuan, Qing
Freeberg, Shelby
Zhu, Pei-Wen
Ye, Lei
Ma, Ming-Yang
Huang, Xin
Shao, Yi
Altered intrinsic brain activities in patients with acute eye pain using amplitude of low-frequency fluctuation: a resting-state fMRI study
title Altered intrinsic brain activities in patients with acute eye pain using amplitude of low-frequency fluctuation: a resting-state fMRI study
title_full Altered intrinsic brain activities in patients with acute eye pain using amplitude of low-frequency fluctuation: a resting-state fMRI study
title_fullStr Altered intrinsic brain activities in patients with acute eye pain using amplitude of low-frequency fluctuation: a resting-state fMRI study
title_full_unstemmed Altered intrinsic brain activities in patients with acute eye pain using amplitude of low-frequency fluctuation: a resting-state fMRI study
title_short Altered intrinsic brain activities in patients with acute eye pain using amplitude of low-frequency fluctuation: a resting-state fMRI study
title_sort altered intrinsic brain activities in patients with acute eye pain using amplitude of low-frequency fluctuation: a resting-state fmri study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767092/
https://www.ncbi.nlm.nih.gov/pubmed/29386898
http://dx.doi.org/10.2147/NDT.S150051
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