Cargando…

Intrinsic and Extrinsic Neuromodulation of Olfactory Processing

Neuromodulation is a ubiquitous feature of neural systems, allowing flexible, context specific control over network dynamics. Neuromodulation was first described in invertebrate motor systems and early work established a basic dichotomy for neuromodulation as having either an intrinsic origin (i.e.,...

Descripción completa

Detalles Bibliográficos
Autores principales: Lizbinski, Kristyn M., Dacks, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767172/
https://www.ncbi.nlm.nih.gov/pubmed/29375314
http://dx.doi.org/10.3389/fncel.2017.00424
_version_ 1783292481991868416
author Lizbinski, Kristyn M.
Dacks, Andrew M.
author_facet Lizbinski, Kristyn M.
Dacks, Andrew M.
author_sort Lizbinski, Kristyn M.
collection PubMed
description Neuromodulation is a ubiquitous feature of neural systems, allowing flexible, context specific control over network dynamics. Neuromodulation was first described in invertebrate motor systems and early work established a basic dichotomy for neuromodulation as having either an intrinsic origin (i.e., neurons that participate in network coding) or an extrinsic origin (i.e., neurons from independent networks). In this conceptual dichotomy, intrinsic sources of neuromodulation provide a “memory” by adjusting network dynamics based upon previous and ongoing activation of the network itself, while extrinsic neuromodulators provide the context of ongoing activity of other neural networks. Although this dichotomy has been thoroughly considered in motor systems, it has received far less attention in sensory systems. In this review, we discuss intrinsic and extrinsic modulation in the context of olfactory processing in invertebrate and vertebrate model systems. We begin by discussing presynaptic modulation of olfactory sensory neurons by local interneurons (LNs) as a mechanism for gain control based on ongoing network activation. We then discuss the cell-class specific effects of serotonergic centrifugal neurons on olfactory processing. Finally, we briefly discuss the integration of intrinsic and extrinsic neuromodulation (metamodulation) as an effective mechanism for exerting global control over olfactory network dynamics. The heterogeneous nature of neuromodulation is a recurring theme throughout this review as the effects of both intrinsic and extrinsic modulation are generally non-uniform.
format Online
Article
Text
id pubmed-5767172
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-57671722018-01-26 Intrinsic and Extrinsic Neuromodulation of Olfactory Processing Lizbinski, Kristyn M. Dacks, Andrew M. Front Cell Neurosci Neuroscience Neuromodulation is a ubiquitous feature of neural systems, allowing flexible, context specific control over network dynamics. Neuromodulation was first described in invertebrate motor systems and early work established a basic dichotomy for neuromodulation as having either an intrinsic origin (i.e., neurons that participate in network coding) or an extrinsic origin (i.e., neurons from independent networks). In this conceptual dichotomy, intrinsic sources of neuromodulation provide a “memory” by adjusting network dynamics based upon previous and ongoing activation of the network itself, while extrinsic neuromodulators provide the context of ongoing activity of other neural networks. Although this dichotomy has been thoroughly considered in motor systems, it has received far less attention in sensory systems. In this review, we discuss intrinsic and extrinsic modulation in the context of olfactory processing in invertebrate and vertebrate model systems. We begin by discussing presynaptic modulation of olfactory sensory neurons by local interneurons (LNs) as a mechanism for gain control based on ongoing network activation. We then discuss the cell-class specific effects of serotonergic centrifugal neurons on olfactory processing. Finally, we briefly discuss the integration of intrinsic and extrinsic neuromodulation (metamodulation) as an effective mechanism for exerting global control over olfactory network dynamics. The heterogeneous nature of neuromodulation is a recurring theme throughout this review as the effects of both intrinsic and extrinsic modulation are generally non-uniform. Frontiers Media S.A. 2018-01-09 /pmc/articles/PMC5767172/ /pubmed/29375314 http://dx.doi.org/10.3389/fncel.2017.00424 Text en Copyright © 2018 Lizbinski and Dacks. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Lizbinski, Kristyn M.
Dacks, Andrew M.
Intrinsic and Extrinsic Neuromodulation of Olfactory Processing
title Intrinsic and Extrinsic Neuromodulation of Olfactory Processing
title_full Intrinsic and Extrinsic Neuromodulation of Olfactory Processing
title_fullStr Intrinsic and Extrinsic Neuromodulation of Olfactory Processing
title_full_unstemmed Intrinsic and Extrinsic Neuromodulation of Olfactory Processing
title_short Intrinsic and Extrinsic Neuromodulation of Olfactory Processing
title_sort intrinsic and extrinsic neuromodulation of olfactory processing
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767172/
https://www.ncbi.nlm.nih.gov/pubmed/29375314
http://dx.doi.org/10.3389/fncel.2017.00424
work_keys_str_mv AT lizbinskikristynm intrinsicandextrinsicneuromodulationofolfactoryprocessing
AT dacksandrewm intrinsicandextrinsicneuromodulationofolfactoryprocessing