Alkaline pH Promotes NADPH Oxidase-Independent Neutrophil Extracellular Trap Formation: A Matter of Mitochondrial Reactive Oxygen Species Generation and Citrullination and Cleavage of Histone

pH is highly variable in different tissues and affects many enzymatic reactions in neutrophils. In response to calcium ionophores such as A23187 and ionomycin, neutrophils undergo nicotinamide adenine dinucleotide phosphate oxidase (NOX)-independent neutrophil extracellular trap (NET) formation (NET...

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Detalles Bibliográficos
Autores principales: Naffah de Souza, Cristiane, Breda, Leandro C. D., Khan, Meraj A., de Almeida, Sandro Rogério, Câmara, Niels Olsen Saraiva, Sweezey, Neil, Palaniyar, Nades
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767187/
https://www.ncbi.nlm.nih.gov/pubmed/29375550
http://dx.doi.org/10.3389/fimmu.2017.01849

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