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Unraveling Natural Killer T-Cells Development

Natural killer T-cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy; however, greater understanding of invariant NKT (iNKT) cell biology is needed. The first step is to learn mo...

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Autor principal: Bennstein, Sabrina Bianca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767218/
https://www.ncbi.nlm.nih.gov/pubmed/29375573
http://dx.doi.org/10.3389/fimmu.2017.01950
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author Bennstein, Sabrina Bianca
author_facet Bennstein, Sabrina Bianca
author_sort Bennstein, Sabrina Bianca
collection PubMed
description Natural killer T-cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy; however, greater understanding of invariant NKT (iNKT) cell biology is needed. The first step is to learn more about NKT development within the thymus. Recent studies suggest lineage separation of murine iNKT cells into iNKT1, iNKT2, and iNKT17 cells instead of shared developmental stages. This review will focus on these new studies and will discuss the evidence for lineage separation in contrast to shared developmental stages. The author will also highlight the classifications of murine iNKT cells according to identified transcription factors and cytokine production, and will discuss transcriptional and posttranscriptional regulations, and the role of mammalian target of rapamycin. Finally, the importance of these findings for human cancer therapy will be briefly discussed.
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spelling pubmed-57672182018-01-26 Unraveling Natural Killer T-Cells Development Bennstein, Sabrina Bianca Front Immunol Immunology Natural killer T-cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy; however, greater understanding of invariant NKT (iNKT) cell biology is needed. The first step is to learn more about NKT development within the thymus. Recent studies suggest lineage separation of murine iNKT cells into iNKT1, iNKT2, and iNKT17 cells instead of shared developmental stages. This review will focus on these new studies and will discuss the evidence for lineage separation in contrast to shared developmental stages. The author will also highlight the classifications of murine iNKT cells according to identified transcription factors and cytokine production, and will discuss transcriptional and posttranscriptional regulations, and the role of mammalian target of rapamycin. Finally, the importance of these findings for human cancer therapy will be briefly discussed. Frontiers Media S.A. 2018-01-09 /pmc/articles/PMC5767218/ /pubmed/29375573 http://dx.doi.org/10.3389/fimmu.2017.01950 Text en Copyright © 2018 Bennstein. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Bennstein, Sabrina Bianca
Unraveling Natural Killer T-Cells Development
title Unraveling Natural Killer T-Cells Development
title_full Unraveling Natural Killer T-Cells Development
title_fullStr Unraveling Natural Killer T-Cells Development
title_full_unstemmed Unraveling Natural Killer T-Cells Development
title_short Unraveling Natural Killer T-Cells Development
title_sort unraveling natural killer t-cells development
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767218/
https://www.ncbi.nlm.nih.gov/pubmed/29375573
http://dx.doi.org/10.3389/fimmu.2017.01950
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