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Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor

Progression to AD is preceded by elevated levels of 2,4-dihydroxybutanoic acid (2,4-DHB), implicating hypoxia in early pathogenesis. Since hypoxia may play a role in multiple CNS disorders, we investigated serum metabolite profiles across three disorders, AD, Normal Pressure Hydrocephalus (NPH) and...

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Detalles Bibliográficos
Autores principales:	Orešič, Matej, Anderson, Gabriella, Mattila, Ismo, Manoucheri, Manoucher, Soininen, Hilkka, Hyötyläinen, Tuulia, Basignani, Cherlynn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767271/ https://www.ncbi.nlm.nih.gov/pubmed/29375291 http://dx.doi.org/10.3389/fnins.2017.00747

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