Cargando…

Does Otovestibular Loss in the Autosomal Dominant Disorder DFNA9 Have an Impact of on Cognition? A Systematic Review

Background and Purpose: Cognitive impairment has been observed in patients with bilateral vestibular loss (BVL) and in patients with sensorineural hearing loss (SNHL). DFNA9 is an autosomal dominant disorder that causes a combination of both sensory deficits by the 3rd to 5th decade. We therefore hy...

Descripción completa

Detalles Bibliográficos
Autores principales: De Belder, Jonas, Matthysen, Stijn, Claes, Annes J., Mertens, Griet, Van de Heyning, Paul, Van Rompaey, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767272/
https://www.ncbi.nlm.nih.gov/pubmed/29375286
http://dx.doi.org/10.3389/fnins.2017.00735
_version_ 1783292506142670848
author De Belder, Jonas
Matthysen, Stijn
Claes, Annes J.
Mertens, Griet
Van de Heyning, Paul
Van Rompaey, Vincent
author_facet De Belder, Jonas
Matthysen, Stijn
Claes, Annes J.
Mertens, Griet
Van de Heyning, Paul
Van Rompaey, Vincent
author_sort De Belder, Jonas
collection PubMed
description Background and Purpose: Cognitive impairment has been observed in patients with bilateral vestibular loss (BVL) and in patients with sensorineural hearing loss (SNHL). DFNA9 is an autosomal dominant disorder that causes a combination of both sensory deficits by the 3rd to 5th decade. We therefore hypothesize a combined detrimental effect on cognition. The aim of this systematic review was to identify studies related to DFNA9 in general and its relationship with cognitive impairment more specifically. Materials and Methods: Several databases including Medline, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, ISI Web of Knowledge, and Web of Science were searched to accumulate information about DFNA9-mutations, including phenotype, genotype, pathophysiology, quality of life (QOL), and imaging in general and cognitive function more specifically. A qualitative analysis was performed on the 55 articles that qualified. Results: The clinical features of DFNA9 are different along the 24 COCH mutations, described up to now. Vestibular symptoms generally present themselves a few years after SNHL onset in mutations associated with the vWFA-domain although they can precede SNHL onset in other mutations associated with the LCCL-domain. QoL has not been studied extensively in DFNA9, although scarce work is available on the positive impact of cochlear implantation to rehabilitate hearing. No studies were found evaluating cognition in DFNA9 patients. Conclusion: Although cognitive impairment has been demonstrated in patients with hearing loss as well as in patients with BVL, no studies have been reported on the combination of both sensory deficits, such as in DFNA9. Further research is warranted to correlate otovestibular status with cognition.
format Online
Article
Text
id pubmed-5767272
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-57672722018-01-26 Does Otovestibular Loss in the Autosomal Dominant Disorder DFNA9 Have an Impact of on Cognition? A Systematic Review De Belder, Jonas Matthysen, Stijn Claes, Annes J. Mertens, Griet Van de Heyning, Paul Van Rompaey, Vincent Front Neurosci Neuroscience Background and Purpose: Cognitive impairment has been observed in patients with bilateral vestibular loss (BVL) and in patients with sensorineural hearing loss (SNHL). DFNA9 is an autosomal dominant disorder that causes a combination of both sensory deficits by the 3rd to 5th decade. We therefore hypothesize a combined detrimental effect on cognition. The aim of this systematic review was to identify studies related to DFNA9 in general and its relationship with cognitive impairment more specifically. Materials and Methods: Several databases including Medline, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, ISI Web of Knowledge, and Web of Science were searched to accumulate information about DFNA9-mutations, including phenotype, genotype, pathophysiology, quality of life (QOL), and imaging in general and cognitive function more specifically. A qualitative analysis was performed on the 55 articles that qualified. Results: The clinical features of DFNA9 are different along the 24 COCH mutations, described up to now. Vestibular symptoms generally present themselves a few years after SNHL onset in mutations associated with the vWFA-domain although they can precede SNHL onset in other mutations associated with the LCCL-domain. QoL has not been studied extensively in DFNA9, although scarce work is available on the positive impact of cochlear implantation to rehabilitate hearing. No studies were found evaluating cognition in DFNA9 patients. Conclusion: Although cognitive impairment has been demonstrated in patients with hearing loss as well as in patients with BVL, no studies have been reported on the combination of both sensory deficits, such as in DFNA9. Further research is warranted to correlate otovestibular status with cognition. Frontiers Media S.A. 2018-01-09 /pmc/articles/PMC5767272/ /pubmed/29375286 http://dx.doi.org/10.3389/fnins.2017.00735 Text en Copyright © 2018 De Belder, Matthysen, Claes, Mertens, Van de Heyning and Van Rompaey. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
De Belder, Jonas
Matthysen, Stijn
Claes, Annes J.
Mertens, Griet
Van de Heyning, Paul
Van Rompaey, Vincent
Does Otovestibular Loss in the Autosomal Dominant Disorder DFNA9 Have an Impact of on Cognition? A Systematic Review
title Does Otovestibular Loss in the Autosomal Dominant Disorder DFNA9 Have an Impact of on Cognition? A Systematic Review
title_full Does Otovestibular Loss in the Autosomal Dominant Disorder DFNA9 Have an Impact of on Cognition? A Systematic Review
title_fullStr Does Otovestibular Loss in the Autosomal Dominant Disorder DFNA9 Have an Impact of on Cognition? A Systematic Review
title_full_unstemmed Does Otovestibular Loss in the Autosomal Dominant Disorder DFNA9 Have an Impact of on Cognition? A Systematic Review
title_short Does Otovestibular Loss in the Autosomal Dominant Disorder DFNA9 Have an Impact of on Cognition? A Systematic Review
title_sort does otovestibular loss in the autosomal dominant disorder dfna9 have an impact of on cognition? a systematic review
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767272/
https://www.ncbi.nlm.nih.gov/pubmed/29375286
http://dx.doi.org/10.3389/fnins.2017.00735
work_keys_str_mv AT debelderjonas doesotovestibularlossintheautosomaldominantdisorderdfna9haveanimpactofoncognitionasystematicreview
AT matthysenstijn doesotovestibularlossintheautosomaldominantdisorderdfna9haveanimpactofoncognitionasystematicreview
AT claesannesj doesotovestibularlossintheautosomaldominantdisorderdfna9haveanimpactofoncognitionasystematicreview
AT mertensgriet doesotovestibularlossintheautosomaldominantdisorderdfna9haveanimpactofoncognitionasystematicreview
AT vandeheyningpaul doesotovestibularlossintheautosomaldominantdisorderdfna9haveanimpactofoncognitionasystematicreview
AT vanrompaeyvincent doesotovestibularlossintheautosomaldominantdisorderdfna9haveanimpactofoncognitionasystematicreview