Cargando…

Multiple Extramedullary Plasmacytoma in a Setting of Complete Bone Marrow Remission: Food for Thought

Extramedullary plasmacytoma as a mode of relapse in multiple myeloma (MM) is unusual. Current recommendations do not incorporate the routine use of 18-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET/CT) imaging prior to haematopoietic stem cell transplant (HSCT) in MM. W...

Descripción completa

Detalles Bibliográficos
Autores principales: Preety, Negi, Alice, Kingsley Pamela, Chinnu, Jomi, Amrith, Mathew, Sneha, George, Vivek, Immanuel, Abraham, Abraham Puliyelil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767287/
https://www.ncbi.nlm.nih.gov/pubmed/29340123
_version_ 1783292509353410560
author Preety, Negi
Alice, Kingsley Pamela
Chinnu, Jomi
Amrith, Mathew
Sneha, George
Vivek, Immanuel
Abraham, Abraham Puliyelil
author_facet Preety, Negi
Alice, Kingsley Pamela
Chinnu, Jomi
Amrith, Mathew
Sneha, George
Vivek, Immanuel
Abraham, Abraham Puliyelil
author_sort Preety, Negi
collection PubMed
description Extramedullary plasmacytoma as a mode of relapse in multiple myeloma (MM) is unusual. Current recommendations do not incorporate the routine use of 18-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET/CT) imaging prior to haematopoietic stem cell transplant (HSCT) in MM. We report a case of relapsed MM with complete remission as per IMWG criteria. In the interim period, before the HSCT, the patient had localizing neurological signs and symptoms attributed to multiple extramedullary plasmacytomas. The uniqueness of this case is that this patient after complete marrow remission with no obvious external masses had unexpected, symptomatic multiple extramedullary plasmacytomas. This case illustrates the need for integration of FDG PET/CT imaging into routine pre-HSCT investigations in relapsed MM to prevent missing any asymptomatic extramedullary plasmacytomas.
format Online
Article
Text
id pubmed-5767287
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center
record_format MEDLINE/PubMed
spelling pubmed-57672872018-01-16 Multiple Extramedullary Plasmacytoma in a Setting of Complete Bone Marrow Remission: Food for Thought Preety, Negi Alice, Kingsley Pamela Chinnu, Jomi Amrith, Mathew Sneha, George Vivek, Immanuel Abraham, Abraham Puliyelil Int J Hematol Oncol Stem Cell Res Case Report Extramedullary plasmacytoma as a mode of relapse in multiple myeloma (MM) is unusual. Current recommendations do not incorporate the routine use of 18-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET/CT) imaging prior to haematopoietic stem cell transplant (HSCT) in MM. We report a case of relapsed MM with complete remission as per IMWG criteria. In the interim period, before the HSCT, the patient had localizing neurological signs and symptoms attributed to multiple extramedullary plasmacytomas. The uniqueness of this case is that this patient after complete marrow remission with no obvious external masses had unexpected, symptomatic multiple extramedullary plasmacytomas. This case illustrates the need for integration of FDG PET/CT imaging into routine pre-HSCT investigations in relapsed MM to prevent missing any asymptomatic extramedullary plasmacytomas. Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2017-10-01 /pmc/articles/PMC5767287/ /pubmed/29340123 Text en Copyright : © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Preety, Negi
Alice, Kingsley Pamela
Chinnu, Jomi
Amrith, Mathew
Sneha, George
Vivek, Immanuel
Abraham, Abraham Puliyelil
Multiple Extramedullary Plasmacytoma in a Setting of Complete Bone Marrow Remission: Food for Thought
title Multiple Extramedullary Plasmacytoma in a Setting of Complete Bone Marrow Remission: Food for Thought
title_full Multiple Extramedullary Plasmacytoma in a Setting of Complete Bone Marrow Remission: Food for Thought
title_fullStr Multiple Extramedullary Plasmacytoma in a Setting of Complete Bone Marrow Remission: Food for Thought
title_full_unstemmed Multiple Extramedullary Plasmacytoma in a Setting of Complete Bone Marrow Remission: Food for Thought
title_short Multiple Extramedullary Plasmacytoma in a Setting of Complete Bone Marrow Remission: Food for Thought
title_sort multiple extramedullary plasmacytoma in a setting of complete bone marrow remission: food for thought
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767287/
https://www.ncbi.nlm.nih.gov/pubmed/29340123
work_keys_str_mv AT preetynegi multipleextramedullaryplasmacytomainasettingofcompletebonemarrowremissionfoodforthought
AT alicekingsleypamela multipleextramedullaryplasmacytomainasettingofcompletebonemarrowremissionfoodforthought
AT chinnujomi multipleextramedullaryplasmacytomainasettingofcompletebonemarrowremissionfoodforthought
AT amrithmathew multipleextramedullaryplasmacytomainasettingofcompletebonemarrowremissionfoodforthought
AT snehageorge multipleextramedullaryplasmacytomainasettingofcompletebonemarrowremissionfoodforthought
AT vivekimmanuel multipleextramedullaryplasmacytomainasettingofcompletebonemarrowremissionfoodforthought
AT abrahamabrahampuliyelil multipleextramedullaryplasmacytomainasettingofcompletebonemarrowremissionfoodforthought