Cargando…

Hematological Reference Intervals for Healthy Iranian Blood Donors

Background: Development of locally-derived hematological reference intervals is necessary for improving the quality of health care and clinical trials. However hematological reference intervals are affected by several variables including age, gender and environmental factors. Therefore this study wa...

Descripción completa

Detalles Bibliográficos
Autores principales: Rasouli, Mahboubeh, Pourmokhtar, Mojgan, Sarkardeh, Shaghayegh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767292/
https://www.ncbi.nlm.nih.gov/pubmed/29340128
_version_ 1783292510514184192
author Rasouli, Mahboubeh
Pourmokhtar, Mojgan
Sarkardeh, Shaghayegh
author_facet Rasouli, Mahboubeh
Pourmokhtar, Mojgan
Sarkardeh, Shaghayegh
author_sort Rasouli, Mahboubeh
collection PubMed
description Background: Development of locally-derived hematological reference intervals is necessary for improving the quality of health care and clinical trials. However hematological reference intervals are affected by several variables including age, gender and environmental factors. Therefore this study was conducted to determine the gender and age-specific hematological reference intervals of healthy Iranian blood donors. Materials and Methods: Selected hematological indices of 394 healthy blood donor volunteers, donating blood at Tehran Blood Transfusion Center were analyzed. Hematological reference intervals, stratified by age and gender were compared. The results of current study were also compared with those of US population. Results: There were significant gender-related differences for mean values of hematological indices, with males having higher mean values of RBC, HCG, HCT and MCV than females. While the mean of PLT and MCH were higher in women. Age-related differences for mean values of RBC and MCH were also significant. The comparison of reference intervals, stratified by both gender and age showed that RBC, HGB and HCT values were higher in males than females in all age groups. But MCH values of females in all age groups and WBC and PLT counts in females older than 30 years were higher compared to the males in the same age group. The results of this study showed some similarity with US population, with narrower intervals. Conclusion: This study suggests that gender and age-specific, locally derived hematological reference intervals should be referred to, before interpretation of any laboratory test result.
format Online
Article
Text
id pubmed-5767292
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center
record_format MEDLINE/PubMed
spelling pubmed-57672922018-01-16 Hematological Reference Intervals for Healthy Iranian Blood Donors Rasouli, Mahboubeh Pourmokhtar, Mojgan Sarkardeh, Shaghayegh Int J Hematol Oncol Stem Cell Res Original Article Background: Development of locally-derived hematological reference intervals is necessary for improving the quality of health care and clinical trials. However hematological reference intervals are affected by several variables including age, gender and environmental factors. Therefore this study was conducted to determine the gender and age-specific hematological reference intervals of healthy Iranian blood donors. Materials and Methods: Selected hematological indices of 394 healthy blood donor volunteers, donating blood at Tehran Blood Transfusion Center were analyzed. Hematological reference intervals, stratified by age and gender were compared. The results of current study were also compared with those of US population. Results: There were significant gender-related differences for mean values of hematological indices, with males having higher mean values of RBC, HCG, HCT and MCV than females. While the mean of PLT and MCH were higher in women. Age-related differences for mean values of RBC and MCH were also significant. The comparison of reference intervals, stratified by both gender and age showed that RBC, HGB and HCT values were higher in males than females in all age groups. But MCH values of females in all age groups and WBC and PLT counts in females older than 30 years were higher compared to the males in the same age group. The results of this study showed some similarity with US population, with narrower intervals. Conclusion: This study suggests that gender and age-specific, locally derived hematological reference intervals should be referred to, before interpretation of any laboratory test result. Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2017-10-01 /pmc/articles/PMC5767292/ /pubmed/29340128 Text en Copyright : © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Rasouli, Mahboubeh
Pourmokhtar, Mojgan
Sarkardeh, Shaghayegh
Hematological Reference Intervals for Healthy Iranian Blood Donors
title Hematological Reference Intervals for Healthy Iranian Blood Donors
title_full Hematological Reference Intervals for Healthy Iranian Blood Donors
title_fullStr Hematological Reference Intervals for Healthy Iranian Blood Donors
title_full_unstemmed Hematological Reference Intervals for Healthy Iranian Blood Donors
title_short Hematological Reference Intervals for Healthy Iranian Blood Donors
title_sort hematological reference intervals for healthy iranian blood donors
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767292/
https://www.ncbi.nlm.nih.gov/pubmed/29340128
work_keys_str_mv AT rasoulimahboubeh hematologicalreferenceintervalsforhealthyiranianblooddonors
AT pourmokhtarmojgan hematologicalreferenceintervalsforhealthyiranianblooddonors
AT sarkardehshaghayegh hematologicalreferenceintervalsforhealthyiranianblooddonors