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Levetiracetam-Induced Skin Hyperpigmentation: An Extremely Rare Undesirable Side Effect
Levetiracetam is one of the newer second-generation antiepileptic drugs with multiple mechanisms of action. Cutaneous side effects due to levetiracetam are rarely reported in the literature. In this article, we describe a patient with skin hyperpigmentation due to the treatment with levetiracetam wi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Epilepsy Society
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767486/ https://www.ncbi.nlm.nih.gov/pubmed/29344468 http://dx.doi.org/10.14581/jer.17016 |
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author | Algahtani, Hussein Marghalani, Siham Satti, Mohamed Shirah, Bader |
author_facet | Algahtani, Hussein Marghalani, Siham Satti, Mohamed Shirah, Bader |
author_sort | Algahtani, Hussein |
collection | PubMed |
description | Levetiracetam is one of the newer second-generation antiepileptic drugs with multiple mechanisms of action. Cutaneous side effects due to levetiracetam are rarely reported in the literature. In this article, we describe a patient with skin hyperpigmentation due to the treatment with levetiracetam with complete resolution after discontinuation of the medication. In addition, we review the topic and hypothesize the mechanism behind this rare complication. To the best of our knowledge, this is the first report of skin hyperpigmentation as a side effect of levetiracetam in the literature. The prescribing physicians should inform the patients about all potential side effect of levetiracetam including skin hyperpigmentation. Similar to many undiagnosed conditions, increased awareness of their existence is the key to diagnosis. Early recognition and timely cessation of therapy are important to reverse this effect. Further studies should be conducted to explore the pathophysiology of this rare side effect. |
format | Online Article Text |
id | pubmed-5767486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Korean Epilepsy Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-57674862018-01-17 Levetiracetam-Induced Skin Hyperpigmentation: An Extremely Rare Undesirable Side Effect Algahtani, Hussein Marghalani, Siham Satti, Mohamed Shirah, Bader J Epilepsy Res Case Report Levetiracetam is one of the newer second-generation antiepileptic drugs with multiple mechanisms of action. Cutaneous side effects due to levetiracetam are rarely reported in the literature. In this article, we describe a patient with skin hyperpigmentation due to the treatment with levetiracetam with complete resolution after discontinuation of the medication. In addition, we review the topic and hypothesize the mechanism behind this rare complication. To the best of our knowledge, this is the first report of skin hyperpigmentation as a side effect of levetiracetam in the literature. The prescribing physicians should inform the patients about all potential side effect of levetiracetam including skin hyperpigmentation. Similar to many undiagnosed conditions, increased awareness of their existence is the key to diagnosis. Early recognition and timely cessation of therapy are important to reverse this effect. Further studies should be conducted to explore the pathophysiology of this rare side effect. Korean Epilepsy Society 2017-12-31 /pmc/articles/PMC5767486/ /pubmed/29344468 http://dx.doi.org/10.14581/jer.17016 Text en Copyright © 2017 Korean Epilepsy Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Algahtani, Hussein Marghalani, Siham Satti, Mohamed Shirah, Bader Levetiracetam-Induced Skin Hyperpigmentation: An Extremely Rare Undesirable Side Effect |
title | Levetiracetam-Induced Skin Hyperpigmentation: An Extremely Rare Undesirable Side Effect |
title_full | Levetiracetam-Induced Skin Hyperpigmentation: An Extremely Rare Undesirable Side Effect |
title_fullStr | Levetiracetam-Induced Skin Hyperpigmentation: An Extremely Rare Undesirable Side Effect |
title_full_unstemmed | Levetiracetam-Induced Skin Hyperpigmentation: An Extremely Rare Undesirable Side Effect |
title_short | Levetiracetam-Induced Skin Hyperpigmentation: An Extremely Rare Undesirable Side Effect |
title_sort | levetiracetam-induced skin hyperpigmentation: an extremely rare undesirable side effect |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767486/ https://www.ncbi.nlm.nih.gov/pubmed/29344468 http://dx.doi.org/10.14581/jer.17016 |
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