Cargando…

Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model

By combining electrophysiological and computational approaches we have examined a series of positive allosteric modulators (PAMs) acting on the human α7 nicotinic acetylcholine receptor (nAChR). Electrophysiological studies have focused on three α7-selective PAMs (A-867744, TBS-516, and TQS) that di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Newcombe, Joseph, Chatzidaki, Anna, Sheppard, Tom D., Topf, Maya, Millar, Neil S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767682/ https://www.ncbi.nlm.nih.gov/pubmed/29196491 http://dx.doi.org/10.1124/mol.117.110551

Ejemplares similares

Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor
por: Smelt, Charles L.C., et al.
Publicado: (2018)

The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors
por: Chatzidaki, Anna, et al.
Publicado: (2015)

Contrasting Properties of α7-Selective Orthosteric and Allosteric Agonists Examined on Native Nicotinic Acetylcholine Receptors
por: Gill, JasKiran K., et al.
Publicado: (2013)

Structurally Similar Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors Exhibit Five Distinct Pharmacological Effects
por: Gill-Thind, JasKiran K., et al.
Publicado: (2015)

Stoichiometry-Selective Antagonism of α4β2 Nicotinic Acetylcholine Receptors by Fluoroquinolone Antibiotics
por: Sanders, Victoria R., et al.
Publicado: (2022)

Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107
por: Mizrachi, Tehila, et al.
Publicado: (2021)

Recent Advances in the Discovery of Nicotinic Acetylcholine Receptor Allosteric Modulators
por: Manetti, Dina, et al.
Publicado: (2023)

Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons
por: Chatzidaki, Anna, et al.
Publicado: (2015)

Menthol acts as a positive allosteric modulator on nematode levamisole sensitive nicotinic acetylcholine receptors
por: Choudhary, Shivani, et al.
Publicado: (2018)

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor
por: Li, Qimeng, et al.
Publicado: (2023)

Menthol Suppresses Nicotinic Acetylcholine Receptor Functioning in Sensory Neurons via Allosteric Modulation
por: Hans, M., et al.
Publicado: (2012)

Orthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking Cessation
por: Mohamed, Tasnim S., et al.
Publicado: (2015)

An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein
por: Delbart, Florian, et al.
Publicado: (2018)

Mutagenesis of α-Conotoxins for Enhancing Activity and Selectivity for Nicotinic Acetylcholine Receptors
por: Turner, Matthew W., et al.
Publicado: (2019)

Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models
por: Kryukova, Elena V., et al.
Publicado: (2018)

Type I-like behavior of the type II α7 nicotinic acetylcholine receptor positive allosteric modulator A-867744
por: Pesti, Krisztina, et al.
Publicado: (2019)

Desformylflustrabromine, a positive allosteric modulator of α4β2-containing nicotinic acetylcholine receptors, enhances cognition in rats
por: Nikiforuk, Agnieszka, et al.
Publicado: (2020)

Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury
por: Titus, David J., et al.
Publicado: (2019)

Positive Allosteric Modulation of Alpha7 Nicotinic Acetylcholine Receptors Transiently Improves Memory but Aggravates Inflammation in LPS-Treated Mice
por: Lykhmus, Olena, et al.
Publicado: (2020)

Allosteric Modulation of Muscarinic Acetylcholine Receptors
por: Gregory, Karen J, et al.
Publicado: (2007)

Allosteric Modulation of Muscarinic Acetylcholine Receptors
por: Jakubík, Jan, et al.
Publicado: (2010)

Corrigendum: Positive Allosteric Modulation of Alpha7 Nicotinic Acetylcholine Receptors Transiently Improves Memory but Aggravates Inflammation in LPS-Treated Mice
por: Lykhmus, Olena, et al.
Publicado: (2020)

An allosteric link connecting the lipid-protein interface to the gating of the nicotinic acetylcholine receptor
por: Domville, Jaimee A., et al.
Publicado: (2018)

Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization
por: Collins, Toby, et al.
Publicado: (2011)

Allosteric modulation of caspase 3 through mutagenesis
por: Walters, Jad, et al.
Publicado: (2012)

Nicotinic acetylcholine receptors modulate osteoclastogenesis
por: Mandl, Peter, et al.
Publicado: (2016)

Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors
por: Ho, Thao NT, et al.
Publicado: (2023)

Examining the Effects of (α4)3(β2)2 Nicotinic Acetylcholine Receptor-Selective Positive Allosteric Modulator on Acute Thermal Nociception in Rats
por: Deba, Farah, et al.
Publicado: (2020)

Negative and positive allosteric modulators of the α7 nicotinic acetylcholine receptor regulates the ability of adolescent binge alcohol exposure to enhance adult alcohol consumption
por: Rodd, Zachary A., et al.
Publicado: (2023)

Activation and allosteric modulation of a muscarinic acetylcholine receptor
por: Kruse, Andrew C., et al.
Publicado: (2013)

Allosterism of Nicotinic Acetylcholine Receptors: Therapeutic Potential for Neuroinflammation Underlying Brain Trauma and Degenerative Disorders
por: Mitra, Swarup, et al.
Publicado: (2020)

Allosteric inhibition of muscle-type nicotinic acetylcholine receptors by a neuromuscular blocking agent pancuronium
por: Sakata, Souhei, et al.
Publicado: (2023)

Attenuation of Compulsive-Like Behavior Through Positive Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors in Non-Induced Compulsive-Like Mice
por: Mitra, Swarup, et al.
Publicado: (2017)

Massive expansion and diversity of nicotinic acetylcholine receptors in lophotrochozoans
por: Jiao, Yu, et al.
Publicado: (2019)

Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine
por: Schapira, Matthieu, et al.
Publicado: (2002)

High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor
por: Groot-Kormelink, Paul J., et al.
Publicado: (2016)

Tracking the Molecular Evolution of Calcium Permeability in a Nicotinic Acetylcholine Receptor
por: Lipovsek, Marcela, et al.
Publicado: (2014)

Evidence for positive allosteric modulation of cognitive-enhancing effects of nicotine in healthy human subjects
por: Hahn, Britta, et al.
Publicado: (2019)

Nicotinic acetylcholine receptor modulator insecticides act on diverse receptor subtypes with distinct subunit compositions
por: Lu, Wanjun, et al.
Publicado: (2022)

Structure-based discovery of selective positive allosteric modulators of antagonists for the M(2) muscarinic acetylcholine receptor
por: Korczynska, Magdalena, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_btv3o6f5gejcbk2s8a3ek3bvqk