A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy

α-Synuclein (α-Syn) aggregation is a pathological feature of synucleinopathies, neurodegenerative disorders that include Parkinson’s disease (PD). We have tested whether N,N,N′,N′-tetramethyl-10H-phenothiazine-3,7-diaminium bis(hydromethanesulfonate) (leuco-methylthioninium bis(hydromethanesulfonate...

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Detalles Bibliográficos
Autores principales: Schwab, Karima, Frahm, Silke, Horsley, David, Rickard, Janet E., Melis, Valeria, Goatman, Elizabeth A., Magbagbeolu, Mandy, Douglas, Morag, Leith, Michael G., Baddeley, Thomas C., Storey, John M. D., Riedel, Gernot, Wischik, Claude M., Harrington, Charles R., Theuring, Franz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767730/
https://www.ncbi.nlm.nih.gov/pubmed/29375308
http://dx.doi.org/10.3389/fnmol.2017.00447

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