A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C

The calcium‐dependent antibiotics (CDAs) are an important emerging class of antibiotics. The crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl‐phosphate at a resolution of 1.28 Å is reported. This is the first crystal structure of a CDA bound to its bacteria...

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Autores principales: Kleijn, Laurens H. J., Vlieg, Hedwich C., Wood, Thomas M., Sastre Toraño, Javier, Janssen, Bert J. C., Martin, Nathaniel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767759/
https://www.ncbi.nlm.nih.gov/pubmed/29108098
http://dx.doi.org/10.1002/anie.201709240
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author Kleijn, Laurens H. J.
Vlieg, Hedwich C.
Wood, Thomas M.
Sastre Toraño, Javier
Janssen, Bert J. C.
Martin, Nathaniel I.
author_facet Kleijn, Laurens H. J.
Vlieg, Hedwich C.
Wood, Thomas M.
Sastre Toraño, Javier
Janssen, Bert J. C.
Martin, Nathaniel I.
author_sort Kleijn, Laurens H. J.
collection PubMed
description The calcium‐dependent antibiotics (CDAs) are an important emerging class of antibiotics. The crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl‐phosphate at a resolution of 1.28 Å is reported. This is the first crystal structure of a CDA bound to its bacterial target. The structure is also the first to be reported for an antibiotic that binds the essential bacterial phospholipid undecaprenyl phosphate (C(55)‐P). These structural insights are of great value in the design of antibiotics capable of exploiting this unique bacterial target.
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spelling pubmed-57677592018-02-01 A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C Kleijn, Laurens H. J. Vlieg, Hedwich C. Wood, Thomas M. Sastre Toraño, Javier Janssen, Bert J. C. Martin, Nathaniel I. Angew Chem Int Ed Engl Communications The calcium‐dependent antibiotics (CDAs) are an important emerging class of antibiotics. The crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl‐phosphate at a resolution of 1.28 Å is reported. This is the first crystal structure of a CDA bound to its bacterial target. The structure is also the first to be reported for an antibiotic that binds the essential bacterial phospholipid undecaprenyl phosphate (C(55)‐P). These structural insights are of great value in the design of antibiotics capable of exploiting this unique bacterial target. John Wiley and Sons Inc. 2017-11-30 2017-12-22 /pmc/articles/PMC5767759/ /pubmed/29108098 http://dx.doi.org/10.1002/anie.201709240 Text en © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Kleijn, Laurens H. J.
Vlieg, Hedwich C.
Wood, Thomas M.
Sastre Toraño, Javier
Janssen, Bert J. C.
Martin, Nathaniel I.
A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C
title A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C
title_full A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C
title_fullStr A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C
title_full_unstemmed A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C
title_short A High‐Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium‐Dependent Lipopeptide Antibiotic Laspartomycin C
title_sort high‐resolution crystal structure that reveals molecular details of target recognition by the calcium‐dependent lipopeptide antibiotic laspartomycin c
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767759/
https://www.ncbi.nlm.nih.gov/pubmed/29108098
http://dx.doi.org/10.1002/anie.201709240
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