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Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases
[Image: see text] p300 and its paralog CBP can acetylate histones and other proteins and have been implicated in a number of diseases characterized by aberrant gene activation, such as cancer. A novel, highly selective, orally bioavailable histone acetyltransferase (HAT) domain inhibitor has been id...
Autores principales: | Michaelides, Michael R., Kluge, Arthur, Patane, Michael, Van Drie, John H., Wang, Ce, Hansen, T. Matthew, Risi, Roberto M., Mantei, Robert, Hertel, Carmen, Karukurichi, Kannan, Nesterov, Alexandre, McElligott, David, de Vries, Peter, Langston, J. William, Cole, Philip A., Marmorstein, Ronen, Liu, Hong, Lasko, Loren, Bromberg, Kenneth D., Lai, Albert, Kesicki, Edward A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2017
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767893/ https://www.ncbi.nlm.nih.gov/pubmed/29348807 http://dx.doi.org/10.1021/acsmedchemlett.7b00395 |
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