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Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women

BACKGROUND: Women undergoing in vitro fertilization (IVF) cycles should successfully go through multiple points during the procedure (i.e., implantation, clinical pregnancy, no spontaneous abortion and delivery) to achieve live births. In this study, data from multiple cycles and multiple points dur...

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Autores principales: Ghaheri, Azadeh, Rasekhi, Aliakbar, Omani Samani, Reza, Hajizadeh, Ebrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royan Institute 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767928/
https://www.ncbi.nlm.nih.gov/pubmed/29334203
http://dx.doi.org/10.22074/ijfs.2018.5187
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author Ghaheri, Azadeh
Rasekhi, Aliakbar
Omani Samani, Reza
Hajizadeh, Ebrahim
author_facet Ghaheri, Azadeh
Rasekhi, Aliakbar
Omani Samani, Reza
Hajizadeh, Ebrahim
author_sort Ghaheri, Azadeh
collection PubMed
description BACKGROUND: Women undergoing in vitro fertilization (IVF) cycles should successfully go through multiple points during the procedure (i.e., implantation, clinical pregnancy, no spontaneous abortion and delivery) to achieve live births. In this study, data from multiple cycles and multiple points during the IVF cycle are collected for each individual to model the effects of factors associated with success at different stages of IVF cycles in Iranian infertile women. MATERIALS AND METHODS: This historical cohort study includes 996 assisted reproductive technology (ART) cycles of 511 infertile women. Covariates considered in this study were women’s age, type of cycle (fresh or frozen embryo transfer), number of embryos transferred and having polycystic ovarian syndrome during IVF cycles. Generalized estimating equations were used for calculation of odds ratio (OR) and 95% confidence intervals (95% CI) of success at different stages during IVF cycles. Cluster-weighted generalized estimating equations (CWGEE) was also fitted to handle informative cluster size. RESULTS: After adjusting for potential confounders, it was seen that receiving frozen embryo transfer was associated with higher odds of success compared to receiving fresh embryo transfer (adj OR: 2.26, 95% CI: 1.66-3.07); however, cycles with fresh embryo transfer exhibited better results in clinical pregnancy compared to those receiving frozen embryo. Being in the age category of 38 to 40 was associated with lower odds of success compared to the reference category (<35) in CWGEE model (adj OR: 0.67, 95% CI: 0.45-1.00). The number of embryos transferred was positively associated with the odds of success in CWGEE (adj OR: 1.21, 95% CI: 1.03-1.42) as well as the GEE model. CONCLUSION: Receiving frozen embryo was positively associated with odds of success compared to cycles with fresh embryo. The number of embryos transferred and women’s age were significantly associated with odds of success.
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spelling pubmed-57679282018-04-01 Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women Ghaheri, Azadeh Rasekhi, Aliakbar Omani Samani, Reza Hajizadeh, Ebrahim Int J Fertil Steril Original Article BACKGROUND: Women undergoing in vitro fertilization (IVF) cycles should successfully go through multiple points during the procedure (i.e., implantation, clinical pregnancy, no spontaneous abortion and delivery) to achieve live births. In this study, data from multiple cycles and multiple points during the IVF cycle are collected for each individual to model the effects of factors associated with success at different stages of IVF cycles in Iranian infertile women. MATERIALS AND METHODS: This historical cohort study includes 996 assisted reproductive technology (ART) cycles of 511 infertile women. Covariates considered in this study were women’s age, type of cycle (fresh or frozen embryo transfer), number of embryos transferred and having polycystic ovarian syndrome during IVF cycles. Generalized estimating equations were used for calculation of odds ratio (OR) and 95% confidence intervals (95% CI) of success at different stages during IVF cycles. Cluster-weighted generalized estimating equations (CWGEE) was also fitted to handle informative cluster size. RESULTS: After adjusting for potential confounders, it was seen that receiving frozen embryo transfer was associated with higher odds of success compared to receiving fresh embryo transfer (adj OR: 2.26, 95% CI: 1.66-3.07); however, cycles with fresh embryo transfer exhibited better results in clinical pregnancy compared to those receiving frozen embryo. Being in the age category of 38 to 40 was associated with lower odds of success compared to the reference category (<35) in CWGEE model (adj OR: 0.67, 95% CI: 0.45-1.00). The number of embryos transferred was positively associated with the odds of success in CWGEE (adj OR: 1.21, 95% CI: 1.03-1.42) as well as the GEE model. CONCLUSION: Receiving frozen embryo was positively associated with odds of success compared to cycles with fresh embryo. The number of embryos transferred and women’s age were significantly associated with odds of success. Royan Institute 2018 2018-01-05 /pmc/articles/PMC5767928/ /pubmed/29334203 http://dx.doi.org/10.22074/ijfs.2018.5187 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ghaheri, Azadeh
Rasekhi, Aliakbar
Omani Samani, Reza
Hajizadeh, Ebrahim
Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women
title Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women
title_full Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women
title_fullStr Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women
title_full_unstemmed Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women
title_short Modeling In Vitro Fertilization Data Considering Multiple Outcomes Observed among Iranian Infertile Women
title_sort modeling in vitro fertilization data considering multiple outcomes observed among iranian infertile women
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767928/
https://www.ncbi.nlm.nih.gov/pubmed/29334203
http://dx.doi.org/10.22074/ijfs.2018.5187
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