Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis

The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after...

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Autores principales: Rohatgi, Soma, Nakouzi, Antonio, Carreño, Leandro J, Slosar-Cheah, Magdalena, Kuniholm, Mark H, Wang, Tao, Pappas, Peter G, Pirofski, Liise-anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767948/
https://www.ncbi.nlm.nih.gov/pubmed/29354657
http://dx.doi.org/10.1093/ofid/ofx255
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author Rohatgi, Soma
Nakouzi, Antonio
Carreño, Leandro J
Slosar-Cheah, Magdalena
Kuniholm, Mark H
Wang, Tao
Pappas, Peter G
Pirofski, Liise-anne
author_facet Rohatgi, Soma
Nakouzi, Antonio
Carreño, Leandro J
Slosar-Cheah, Magdalena
Kuniholm, Mark H
Wang, Tao
Pappas, Peter G
Pirofski, Liise-anne
author_sort Rohatgi, Soma
collection PubMed
description The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis.
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spelling pubmed-57679482018-01-19 Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis Rohatgi, Soma Nakouzi, Antonio Carreño, Leandro J Slosar-Cheah, Magdalena Kuniholm, Mark H Wang, Tao Pappas, Peter G Pirofski, Liise-anne Open Forum Infect Dis Brief Report The importance of antibody immunity in protection against Cryptococcus neoformans remains unresolved. We measured serum C neoformans-specific and total antibody levels and peripheral blood B cell subsets of 12 previously healthy patients with cryptococcosis (cases) and 21 controls. Before and after adjustment for age, sex, and race, cryptococcal capsular polysaccharide immunoglobulin G was higher in cases than controls, whereas total B and memory B cell levels were lower. These associations parallel previous findings in patients with human immunodeficiency virus-associated cryptococcosis and suggest that B cell subset perturbations may also associate with disease in previously normal individuals with cryptococcosis. Oxford University Press 2017-11-18 /pmc/articles/PMC5767948/ /pubmed/29354657 http://dx.doi.org/10.1093/ofid/ofx255 Text en © The Author(s) 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Rohatgi, Soma
Nakouzi, Antonio
Carreño, Leandro J
Slosar-Cheah, Magdalena
Kuniholm, Mark H
Wang, Tao
Pappas, Peter G
Pirofski, Liise-anne
Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis
title Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis
title_full Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis
title_fullStr Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis
title_full_unstemmed Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis
title_short Antibody and B Cell Subset Perturbations in Human Immunodeficiency Virus-Uninfected Patients With Cryptococcosis
title_sort antibody and b cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767948/
https://www.ncbi.nlm.nih.gov/pubmed/29354657
http://dx.doi.org/10.1093/ofid/ofx255
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