Decay of HIV DNA in the Reservoir and the Impact of Short Treatment Interruption in Kenyan Infants

We compared change in HIV reservoir DNA following continued antiretroviral therapy (ART) vs short treatment interruption (TI) in early ART-treated Kenyan infants. While HIV DNA in the reservoir decayed with continued ART, HIV DNA levels were similar to pre-TI HIV DNA reservoir levels in most childre...

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Autores principales: Pankau, Mark D, Wamalwa, Dalton, Benki-Nugent, Sarah, Tapia, Kenneth, Ngugi, Evelyn, Langat, Agnes, Otieno, Vincent, Moraa, Helen, Maleche-Obimbo, Elizabeth, Overbaugh, Julie, John-Stewart, Grace C, Lehman, Dara A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767951/
https://www.ncbi.nlm.nih.gov/pubmed/29354661
http://dx.doi.org/10.1093/ofid/ofx268
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author Pankau, Mark D
Wamalwa, Dalton
Benki-Nugent, Sarah
Tapia, Kenneth
Ngugi, Evelyn
Langat, Agnes
Otieno, Vincent
Moraa, Helen
Maleche-Obimbo, Elizabeth
Overbaugh, Julie
John-Stewart, Grace C
Lehman, Dara A
author_facet Pankau, Mark D
Wamalwa, Dalton
Benki-Nugent, Sarah
Tapia, Kenneth
Ngugi, Evelyn
Langat, Agnes
Otieno, Vincent
Moraa, Helen
Maleche-Obimbo, Elizabeth
Overbaugh, Julie
John-Stewart, Grace C
Lehman, Dara A
author_sort Pankau, Mark D
collection PubMed
description We compared change in HIV reservoir DNA following continued antiretroviral therapy (ART) vs short treatment interruption (TI) in early ART-treated Kenyan infants. While HIV DNA in the reservoir decayed with continued ART, HIV DNA levels were similar to pre-TI HIV DNA reservoir levels in most children after short TI.
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spelling pubmed-57679512018-01-19 Decay of HIV DNA in the Reservoir and the Impact of Short Treatment Interruption in Kenyan Infants Pankau, Mark D Wamalwa, Dalton Benki-Nugent, Sarah Tapia, Kenneth Ngugi, Evelyn Langat, Agnes Otieno, Vincent Moraa, Helen Maleche-Obimbo, Elizabeth Overbaugh, Julie John-Stewart, Grace C Lehman, Dara A Open Forum Infect Dis Brief Report We compared change in HIV reservoir DNA following continued antiretroviral therapy (ART) vs short treatment interruption (TI) in early ART-treated Kenyan infants. While HIV DNA in the reservoir decayed with continued ART, HIV DNA levels were similar to pre-TI HIV DNA reservoir levels in most children after short TI. Oxford University Press 2017-12-09 /pmc/articles/PMC5767951/ /pubmed/29354661 http://dx.doi.org/10.1093/ofid/ofx268 Text en © The Author(s) 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Pankau, Mark D
Wamalwa, Dalton
Benki-Nugent, Sarah
Tapia, Kenneth
Ngugi, Evelyn
Langat, Agnes
Otieno, Vincent
Moraa, Helen
Maleche-Obimbo, Elizabeth
Overbaugh, Julie
John-Stewart, Grace C
Lehman, Dara A
Decay of HIV DNA in the Reservoir and the Impact of Short Treatment Interruption in Kenyan Infants
title Decay of HIV DNA in the Reservoir and the Impact of Short Treatment Interruption in Kenyan Infants
title_full Decay of HIV DNA in the Reservoir and the Impact of Short Treatment Interruption in Kenyan Infants
title_fullStr Decay of HIV DNA in the Reservoir and the Impact of Short Treatment Interruption in Kenyan Infants
title_full_unstemmed Decay of HIV DNA in the Reservoir and the Impact of Short Treatment Interruption in Kenyan Infants
title_short Decay of HIV DNA in the Reservoir and the Impact of Short Treatment Interruption in Kenyan Infants
title_sort decay of hiv dna in the reservoir and the impact of short treatment interruption in kenyan infants
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767951/
https://www.ncbi.nlm.nih.gov/pubmed/29354661
http://dx.doi.org/10.1093/ofid/ofx268
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