The effect of an adenosine A(2A) agonist on intra-tumoral concentrations of temozolomide in patients with recurrent glioblastoma

BACKGROUND: The blood–brain barrier (BBB) severely limits the entry of systemically administered drugs including chemotherapy to the brain. In rodents, regadenoson activation of adenosine A(2A) receptors causes transient BBB disruption and increased drug concentrations in normal brain. This study wa...

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Detalles Bibliográficos
Autores principales: Jackson, Sadhana, Weingart, Jon, Nduom, Edjah K., Harfi, Thura T., George, Richard T., McAreavey, Dorothea, Ye, Xiaobu, Anders, Nicole M., Peer, Cody, Figg, William D., Gilbert, Mark, Rudek, Michelle A., Grossman, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767971/
https://www.ncbi.nlm.nih.gov/pubmed/29332604
http://dx.doi.org/10.1186/s12987-017-0088-8

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