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Evaluation of dosimetric advantages of using patient‐specific aperture system with intensity‐modulated proton therapy for the shallow depth tumor

In this study, we evaluate dosimetric advantages of using patient‐specific aperture system with intensity‐modulated proton therapy (IMPT) for head and neck tumors at the shallow depth. We used four types of patient‐specific aperture system (PSAS) to irradiate shallow regions less than 4 g/cm(2) with...

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Autores principales: Yasui, Keisuke, Toshito, Toshiyuki, Omachi, Chihiro, Hayashi, Kensuke, Tanaka, Kenichiro, Asai, Kumiko, Shimomura, Akira, Muramatsu, Rie, Hayashi, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768032/
https://www.ncbi.nlm.nih.gov/pubmed/29178546
http://dx.doi.org/10.1002/acm2.12231
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author Yasui, Keisuke
Toshito, Toshiyuki
Omachi, Chihiro
Hayashi, Kensuke
Tanaka, Kenichiro
Asai, Kumiko
Shimomura, Akira
Muramatsu, Rie
Hayashi, Naoki
author_facet Yasui, Keisuke
Toshito, Toshiyuki
Omachi, Chihiro
Hayashi, Kensuke
Tanaka, Kenichiro
Asai, Kumiko
Shimomura, Akira
Muramatsu, Rie
Hayashi, Naoki
author_sort Yasui, Keisuke
collection PubMed
description In this study, we evaluate dosimetric advantages of using patient‐specific aperture system with intensity‐modulated proton therapy (IMPT) for head and neck tumors at the shallow depth. We used four types of patient‐specific aperture system (PSAS) to irradiate shallow regions less than 4 g/cm(2) with a sharp lateral penumbra. Ten head and neck IMPT plans with or without aperture were optimized separately with the same 95% prescription dose and same dose constraint for organs at risk (OARs). The plans were compared using dose volume histograms (DVHs), dose distributions, and some dose indexes such as volume receiving 50% of the prescribed dose (V(50)), mean or maximum dose (D(mean) and D(max)) to the OARs. All examples verified in this study had decreased V(50) and OAR doses. Average, maximum, and minimum relative reductions of V(50) were 15.4%, 38.9%, and 1.0%, respectively. D(max) and D(mean) of OARs were decreased by 0.3% to 25.7% and by 1.0% to 46.3%, respectively. The plans with the aperture over more than half of the field showed decreased V(50) or OAR dose by more than 10%. The dosimetric advantage of patient‐specific apertures with IMPT was clarified in many cases. The PSAS has some dosimetric advantages for clinical use, and in some cases, it enables to fulfill dose constraints.
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spelling pubmed-57680322018-04-02 Evaluation of dosimetric advantages of using patient‐specific aperture system with intensity‐modulated proton therapy for the shallow depth tumor Yasui, Keisuke Toshito, Toshiyuki Omachi, Chihiro Hayashi, Kensuke Tanaka, Kenichiro Asai, Kumiko Shimomura, Akira Muramatsu, Rie Hayashi, Naoki J Appl Clin Med Phys Radiation Oncology Physics In this study, we evaluate dosimetric advantages of using patient‐specific aperture system with intensity‐modulated proton therapy (IMPT) for head and neck tumors at the shallow depth. We used four types of patient‐specific aperture system (PSAS) to irradiate shallow regions less than 4 g/cm(2) with a sharp lateral penumbra. Ten head and neck IMPT plans with or without aperture were optimized separately with the same 95% prescription dose and same dose constraint for organs at risk (OARs). The plans were compared using dose volume histograms (DVHs), dose distributions, and some dose indexes such as volume receiving 50% of the prescribed dose (V(50)), mean or maximum dose (D(mean) and D(max)) to the OARs. All examples verified in this study had decreased V(50) and OAR doses. Average, maximum, and minimum relative reductions of V(50) were 15.4%, 38.9%, and 1.0%, respectively. D(max) and D(mean) of OARs were decreased by 0.3% to 25.7% and by 1.0% to 46.3%, respectively. The plans with the aperture over more than half of the field showed decreased V(50) or OAR dose by more than 10%. The dosimetric advantage of patient‐specific apertures with IMPT was clarified in many cases. The PSAS has some dosimetric advantages for clinical use, and in some cases, it enables to fulfill dose constraints. John Wiley and Sons Inc. 2017-11-27 /pmc/articles/PMC5768032/ /pubmed/29178546 http://dx.doi.org/10.1002/acm2.12231 Text en © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Yasui, Keisuke
Toshito, Toshiyuki
Omachi, Chihiro
Hayashi, Kensuke
Tanaka, Kenichiro
Asai, Kumiko
Shimomura, Akira
Muramatsu, Rie
Hayashi, Naoki
Evaluation of dosimetric advantages of using patient‐specific aperture system with intensity‐modulated proton therapy for the shallow depth tumor
title Evaluation of dosimetric advantages of using patient‐specific aperture system with intensity‐modulated proton therapy for the shallow depth tumor
title_full Evaluation of dosimetric advantages of using patient‐specific aperture system with intensity‐modulated proton therapy for the shallow depth tumor
title_fullStr Evaluation of dosimetric advantages of using patient‐specific aperture system with intensity‐modulated proton therapy for the shallow depth tumor
title_full_unstemmed Evaluation of dosimetric advantages of using patient‐specific aperture system with intensity‐modulated proton therapy for the shallow depth tumor
title_short Evaluation of dosimetric advantages of using patient‐specific aperture system with intensity‐modulated proton therapy for the shallow depth tumor
title_sort evaluation of dosimetric advantages of using patient‐specific aperture system with intensity‐modulated proton therapy for the shallow depth tumor
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768032/
https://www.ncbi.nlm.nih.gov/pubmed/29178546
http://dx.doi.org/10.1002/acm2.12231
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