Cargando…

Circular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice

Circular non-coding RNAs are found to play important roles in biology but are still relatively unexplored as a structural motif for chemically regulating gene function. Here, we investigated whether small interfering RNA (siRNA) with a circular structure can circumvent off-target gene silencing, a p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Liangliang, Liang, Duanwei, Chen, Changmai, Wang, Yuan, Amu, Gubu, Yang, Jiali, Yu, Lijia, Dmochowski, Ivan J., Tang, Xinjing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768153/ https://www.ncbi.nlm.nih.gov/pubmed/29499936 http://dx.doi.org/10.1016/j.omtn.2017.12.007

Ejemplares similares

Tetrazine-Induced Bioorthogonal Activation of Vitamin E-Modified siRNA for Gene Silencing
por: Zhang, Xueli, et al.
Publicado: (2022)

Caged circular siRNAs for photomodulation of gene expression in cells and mice
por: Zhang, Liangliang, et al.
Publicado: (2017)

Multimerized self-assembled caged two-in-one siRNA nanoparticles for photomodulation of RNAi-induced gene silencing
por: Chen, Changmai, et al.
Publicado: (2020)

A Photochemical Avenue to Photoluminescent N-Dots and their Upconversion Cell Imaging
por: Jin, Qingqing, et al.
Publicado: (2017)

Primary and Secondary siRNAs in Geminivirus-induced Gene Silencing
por: Aregger, Michael, et al.
Publicado: (2012)

Optimal choice of functional and off-target effect-reduced siRNAs for RNAi therapeutics
por: Ui-Tei, Kumiko
Publicado: (2013)

GW body disassembly triggered by siRNAs independently of their silencing activity
por: Serman, A., et al.
Publicado: (2007)

Differences in silencing of mismatched targets by sliced versus diced siRNAs
por: Sun, Guihua, et al.
Publicado: (2018)

Carrier-free cellular uptake and the gene-silencing activity of the lipophilic siRNAs is strongly affected by the length of the linker between siRNA and lipophilic group
por: Petrova, Natalya S., et al.
Publicado: (2012)

Designing of Highly Effective Complementary and Mismatch siRNAs for Silencing a Gene
por: Ahmed, Firoz, et al.
Publicado: (2011)

Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs
por: Vaish, Narendra, et al.
Publicado: (2011)

Synthesis and Gene Silencing Properties of siRNAs Containing Terminal Amide Linkages
por: Gaglione, Maria, et al.
Publicado: (2014)

Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth
por: Khan, Tayeba, et al.
Publicado: (2016)

Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche
por: Krohn-Grimberghe, Marvin, et al.
Publicado: (2020)

Effective carrier-free gene-silencing activity of cholesterol-modified siRNAs
por: Salim, Lidya, et al.
Publicado: (2018)

Cheminformatics Modeling of Gene Silencing for Both Natural and Chemically Modified siRNAs
por: Dong, Xialan, et al.
Publicado: (2022)

siRNA-mediated off-target gene silencing triggered by a 7 nt complementation
por: Lin, Xiaoyu, et al.
Publicado: (2005)

Minimizing off-target effects by using diced siRNAs for RNA interference
por: Myers, Jason W, et al.
Publicado: (2006)

Therapeutic siRNA silencing in inflammatory monocytes
por: Leuschner, Florian, et al.
Publicado: (2011)

Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline
por: Klenov, Mikhail S., et al.
Publicado: (2007)

siRNAs and DNA Methylation Do a Two-Step to Silence Tandem Sequences
por: Robinson, Richard
Publicado: (2006)

Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing
por: Brown, Jonathan M., et al.
Publicado: (2019)

Role of siRNAs and miRNAs in the processes of RNA-mediated gene silencing during viral infections
por: Krulko, I., et al.
Publicado: (2009)

BmNPV p35 Reduces the Accumulation of Virus-Derived siRNAs and Hinders the Function of siRNAs to Facilitate Viral Infection
por: Zhao, Shudi, et al.
Publicado: (2022)

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
por: Janas, Maja M., et al.
Publicado: (2018)

Rationally designed siRNAs without miRNA-like off-target repression
por: Seok, Heeyoung, et al.
Publicado: (2016)

Where should siRNAs go: applicable organs for siRNA drugs
por: Ahn, Insook, et al.
Publicado: (2023)

Nuclear-targeted siRNA delivery for long-term gene silencing
por: Li, Na, et al.
Publicado: (2017)

More complete gene silencing by fewer siRNAs: transparent optimized design and biophysical signature
por: Ladunga, Istvan
Publicado: (2007)

Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain
por: Alterman, Julia F, et al.
Publicado: (2015)

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models
por: Conroy, Faith, et al.
Publicado: (2022)

Nanocarriers for delivery of siRNA as gene silencing mediator
por: Morales-Becerril, Aideé, et al.
Publicado: (2022)

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect
por: Ui-Tei, Kumiko, et al.
Publicado: (2008)

Whole-Genome Thermodynamic Analysis Reduces siRNA Off-Target Effects
por: Chen, Xi, et al.
Publicado: (2013)

siRNA Specificity: RNAi Mechanisms and Strategies to Reduce Off-Target Effects
por: Neumeier, Julia, et al.
Publicado: (2021)

Feasibility of cRGD conjugation at 5′-antisense strand of siRNA by phosphodiester linkage extension
por: Zhou, Xinyang, et al.
Publicado: (2021)

Knocking down Disease with siRNAs
por: Dykxhoorn, Derek M., et al.
Publicado: (2006)

Selective silencing of DNA topoisomerase IIβ in human mesenchymal stem cells by siRNAs (small interfering RNAs)
por: Kamaci, Nebiyyeh, et al.
Publicado: (2011)

Identification of ta-siRNAs and Cis-nat-siRNAs in Cassava and Their Roles in Response to Cassava Bacterial Blight
por: Quintero, Andrés, et al.
Publicado: (2013)

siRNAs with decreased off-target effect facilitate the identification of essential genes in cancer cells
por: Li, Chunyan, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_c5t0d70opeg434gou8c75topoq