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Toxic elements as biomarkers for breast cancer: a meta-analysis study

AIMS AND BACKGROUND: Breast cancer (BC) is responsible for a large proportion of incidence of cancer in the world. Identifying the risk factors contributing to the incidence of BC is crucial to find efficient preventive and management strategies for this disease. Several studies have examined Arseni...

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Autores principales: Jouybari, Leila, Saei Ghare Naz, Marzieh, Sanagoo, Akram, Kiani, Faezeh, Sayehmiri, Fatemeh, Sayehmiri, Kourosh, Hasanpour Dehkordi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768192/
https://www.ncbi.nlm.nih.gov/pubmed/29391828
http://dx.doi.org/10.2147/CMAR.S151324
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author Jouybari, Leila
Saei Ghare Naz, Marzieh
Sanagoo, Akram
Kiani, Faezeh
Sayehmiri, Fatemeh
Sayehmiri, Kourosh
Hasanpour Dehkordi, Ali
author_facet Jouybari, Leila
Saei Ghare Naz, Marzieh
Sanagoo, Akram
Kiani, Faezeh
Sayehmiri, Fatemeh
Sayehmiri, Kourosh
Hasanpour Dehkordi, Ali
author_sort Jouybari, Leila
collection PubMed
description AIMS AND BACKGROUND: Breast cancer (BC) is responsible for a large proportion of incidence of cancer in the world. Identifying the risk factors contributing to the incidence of BC is crucial to find efficient preventive and management strategies for this disease. Several studies have examined Arsenic (As), Cadmium (Cd), and Nickel (Ni) as risk factors for BC. The present study aimed at studying the link between As, Cd, and Ni concentrations and BC by using a meta-analysis. MATERIALS AND METHODS: All case–control studies addressing the relationship between As, Cd, and Ni concentrations with BC were identified through electronic search databases (Scopus, ISI Web of Science, PubMed, EmBase, and Cochrane Library). The relevant data obtained from these papers were analyzed by a random-effects model. The heterogeneity of studies was secured by using I(2) index. Funnel plots and Egger’s test were used to examine publication bias. RESULTS: In the present study, due to different measurement methods used for measuring As, Cd, and Ni, the concentration of these elements was measured in various subgroups (1: plasma, 2: breast tissue, and 3: scalp hair and nail) of individuals with BC and healthy subjects. The overall integration of data from the 3 groups led to the conclusion that there was a significant difference in Cd and Ni statuses between healthy and BC patients; the standard mean difference was 2.65 (95% CI: 1.57–3.73; P=0.000) and 2.06 (95% CI: 1.20–3.32; P=0.000), respectively. Whereas, there was no significant statistical difference in As status between healthy subjects and BC patients; the standard mean difference between them being 0.52 (95% CI: –0.12–1.16; P=0.114). CONCLUSION: The present study indicates that there is a direct and positive association between Cd and Ni concentrations and BC risk. It is a warning to health care providers and policy makers to find viable solutions and take requisite measures to reduce BC risk in the society.
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spelling pubmed-57681922018-02-01 Toxic elements as biomarkers for breast cancer: a meta-analysis study Jouybari, Leila Saei Ghare Naz, Marzieh Sanagoo, Akram Kiani, Faezeh Sayehmiri, Fatemeh Sayehmiri, Kourosh Hasanpour Dehkordi, Ali Cancer Manag Res Review AIMS AND BACKGROUND: Breast cancer (BC) is responsible for a large proportion of incidence of cancer in the world. Identifying the risk factors contributing to the incidence of BC is crucial to find efficient preventive and management strategies for this disease. Several studies have examined Arsenic (As), Cadmium (Cd), and Nickel (Ni) as risk factors for BC. The present study aimed at studying the link between As, Cd, and Ni concentrations and BC by using a meta-analysis. MATERIALS AND METHODS: All case–control studies addressing the relationship between As, Cd, and Ni concentrations with BC were identified through electronic search databases (Scopus, ISI Web of Science, PubMed, EmBase, and Cochrane Library). The relevant data obtained from these papers were analyzed by a random-effects model. The heterogeneity of studies was secured by using I(2) index. Funnel plots and Egger’s test were used to examine publication bias. RESULTS: In the present study, due to different measurement methods used for measuring As, Cd, and Ni, the concentration of these elements was measured in various subgroups (1: plasma, 2: breast tissue, and 3: scalp hair and nail) of individuals with BC and healthy subjects. The overall integration of data from the 3 groups led to the conclusion that there was a significant difference in Cd and Ni statuses between healthy and BC patients; the standard mean difference was 2.65 (95% CI: 1.57–3.73; P=0.000) and 2.06 (95% CI: 1.20–3.32; P=0.000), respectively. Whereas, there was no significant statistical difference in As status between healthy subjects and BC patients; the standard mean difference between them being 0.52 (95% CI: –0.12–1.16; P=0.114). CONCLUSION: The present study indicates that there is a direct and positive association between Cd and Ni concentrations and BC risk. It is a warning to health care providers and policy makers to find viable solutions and take requisite measures to reduce BC risk in the society. Dove Medical Press 2018-01-10 /pmc/articles/PMC5768192/ /pubmed/29391828 http://dx.doi.org/10.2147/CMAR.S151324 Text en © 2018 Jouybari et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Jouybari, Leila
Saei Ghare Naz, Marzieh
Sanagoo, Akram
Kiani, Faezeh
Sayehmiri, Fatemeh
Sayehmiri, Kourosh
Hasanpour Dehkordi, Ali
Toxic elements as biomarkers for breast cancer: a meta-analysis study
title Toxic elements as biomarkers for breast cancer: a meta-analysis study
title_full Toxic elements as biomarkers for breast cancer: a meta-analysis study
title_fullStr Toxic elements as biomarkers for breast cancer: a meta-analysis study
title_full_unstemmed Toxic elements as biomarkers for breast cancer: a meta-analysis study
title_short Toxic elements as biomarkers for breast cancer: a meta-analysis study
title_sort toxic elements as biomarkers for breast cancer: a meta-analysis study
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768192/
https://www.ncbi.nlm.nih.gov/pubmed/29391828
http://dx.doi.org/10.2147/CMAR.S151324
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