LKB1 loss cooperating with BRAF V600E promotes melanoma cell invasion and migration by up-regulation MMP-2 via PI3K/Akt/mTOR pathway

The serine/threonine kinase LKB1, act as a tumor suppressor, has been reported in several sporadic cancers. However, how the loss of LKB1 promotes melanoma invasion and metastasis remains incompletely understood. In this study, we inactivated LKB1expression by RNA interference in BRAF mutation and w...

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Detalles Bibliográficos
Autores principales: Zhang, Weiming, Yin, Li, Song, Guoxin, Han, Xue, Yin, Zhiqiang, Luo, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768368/
https://www.ncbi.nlm.nih.gov/pubmed/29371951
http://dx.doi.org/10.18632/oncotarget.22943

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768368/
https://www.ncbi.nlm.nih.gov/pubmed/29371951
http://dx.doi.org/10.18632/oncotarget.22943

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