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A comparative global phosphoproteomics analysis of obinutuzumab (GA101) versus rituximab (RTX) against RTX sensitive and resistant Burkitt lymphoma (BL) demonstrates differential phosphorylation of signaling pathway proteins after treatment
We recently demonstrated that obinutuzumab (GA101), a novel glycoengineered type II CD20 Ab compared to rituximab (RTX) mediates significantly enhanced antibody-dependent cell cytotoxicity (ADCC) in vitro and increased overall survival in a Burkitt lymphoma (BL) xenograft non-obese diabetic severe c...
Autores principales: | Awasthi, Aradhana, Rolland, Delphine C.M., Ayello, Janet, van de Ven, Carmella, Basrur, Venkatesha, Conlon, Kevin, Fermin, Damian, Barth, Matthew J, Klein, Christian, Elenitoba-Johnson, Kojo S.J., Lim, Megan S., Cairo, Mitchell S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768372/ https://www.ncbi.nlm.nih.gov/pubmed/29371955 http://dx.doi.org/10.18632/oncotarget.23040 |
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