Modulating the metabolism by trimetazidine enhances myoblast differentiation and promotes myogenesis in cachectic tumor-bearing c26 mice

Trimetazidine (TMZ) is a metabolic reprogramming agent able to partially inhibit mitochondrial free fatty acid β-oxidation while enhancing glucose oxidation. Here we have found that the metabolic shift driven by TMZ enhances the myogenic potential of skeletal muscle progenitor cells leading to MyoD,...

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Detalles Bibliográficos
Autores principales: Gatta, Lucia, Vitiello, Laura, Gorini, Stefania, Chiandotto, Sergio, Costelli, Paola, Giammarioli, Anna Maria, Malorni, Walter, Rosano, Giuseppe, Ferraro, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768376/
https://www.ncbi.nlm.nih.gov/pubmed/29371959
http://dx.doi.org/10.18632/oncotarget.23044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768376/
https://www.ncbi.nlm.nih.gov/pubmed/29371959
http://dx.doi.org/10.18632/oncotarget.23044

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